Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/17739
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dc.contributor.authorBrown, Belinda M-
dc.contributor.authorRainey-Smith, Stephanie R-
dc.contributor.authorDore, Vincent-
dc.contributor.authorPeiffer, Jeremiah J-
dc.contributor.authorBurnham, Samantha C-
dc.contributor.authorLaws, Simon M-
dc.contributor.authorTaddei, Kevin-
dc.contributor.authorAmes, David-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorVillemagne, Victor L-
dc.date2018-05-11-
dc.date.accessioned2018-05-17T03:50:24Z-
dc.date.available2018-05-17T03:50:24Z-
dc.date.issued2018-05-11-
dc.identifier.citationJournal of Alzheimer's disease : JAD 2018; online first: 11 May-
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/17739-
dc.description.abstractNumerous animal studies have reported exercise reduces the accumulation of Alzheimer's disease pathology, including amyloid-β (Aβ) and tau. Furthermore, we previously reported a relationship between higher levels of physical activity (PA) and lower brain Aβ burden in a human population. The recent advent of tau positron emission tomography (PET) tracers enables us to extend our investigations into the evaluation of the relationship between PA and brain tau burden. Utilizing data from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, we have examined the cross-sectional relationship between habitual PA and PET-quantified tau burden. Forty-three cognitively healthy older adults were categorized into low-moderate PA (LMPA; n = 16) or high PA (HPA; n = 27), based on self-reported PA levels. Tau PET imaging with the AV1451 tracer was conducted on all participants. The LMPA group had significantly higher neocortical tau burden (presented as a z-score; 1.22±1.98), compared to the HPA group (z-score: - 0.28±1.18). The difference between the LMPA and HPA groups was also evident when examining regional tau burden in the temporoparietal cortex and the prefrontal cortex. Our results suggest an association between self-reported PA level and brain tau burden. Future longitudinal and interventional studies utilizing larger samples sizes are vital to further investigate the nature of the relationship between tau and PA.-
dc.language.isoeng-
dc.subjectAlzheimer’s disease-
dc.subjectphysical activity-
dc.subjectpositron emission tomography-
dc.subjecttau-
dc.titleSelf-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography.-
dc.typeJournal Article-
dc.identifier.journaltitleJournal of Alzheimer's disease : JAD-
dc.identifier.affiliationSchool of Psychology and Exercise Science, Murdoch University, Murdoch, WA, Australia-
dc.identifier.affiliationSir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Nedlands, WA, Australia-
dc.identifier.affiliationeHealth, CSIRO Health and Biosecurity, Herston, QLD, Australia-
dc.identifier.affiliationeHealth, CSIRO Health and Biosecurity, Parkville, VIC, Australia-
dc.identifier.affiliationCollaborative Genomics Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia-
dc.identifier.affiliationSchool of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, WA, Australia-
dc.identifier.affiliationCooperative Research Centre for Mental Health, http://www.mentalhealthcrc.com-
dc.identifier.affiliationSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia-
dc.identifier.affiliationDepartment of Psychiatry, University of Melbourne, VIC, Australia-
dc.identifier.affiliationNational Ageing Research Institute, Parkville, VIC, Australia-
dc.identifier.affiliationFlorey Institute for Neurosciences and Mental Health, University of Melbourne, VIC, Australia-
dc.identifier.affiliationDepartment of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia-
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.doi10.3233/JAD-170998-
dc.identifier.orcid0000-0003-3910-2453-
dc.identifier.pubmedid29758940-
Appears in Collections:Journal articles

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