Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/17739
Title: Self-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography.
Authors: Brown, Belinda M;Rainey-Smith, Stephanie R;Dore, Vincent;Peiffer, Jeremiah J;Burnham, Samantha C;Laws, Simon M;Taddei, Kevin;Ames, David;Masters, Colin L;Rowe, Christopher C;Martins, Ralph N;Villemagne, Victor L
Affiliation: School of Psychology and Exercise Science, Murdoch University, Murdoch, WA, Australia
Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Nedlands, WA, Australia
eHealth, CSIRO Health and Biosecurity, Herston, QLD, Australia
eHealth, CSIRO Health and Biosecurity, Parkville, VIC, Australia
Collaborative Genomics Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
School of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, WA, Australia
Cooperative Research Centre for Mental Health, http://www.mentalhealthcrc.com
School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
Department of Psychiatry, University of Melbourne, VIC, Australia
National Ageing Research Institute, Parkville, VIC, Australia
Florey Institute for Neurosciences and Mental Health, University of Melbourne, VIC, Australia
Department of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 11-May-2018
EDate: 2018-05-11
Citation: Journal of Alzheimer's disease : JAD 2018; online first: 11 May
Abstract: Numerous animal studies have reported exercise reduces the accumulation of Alzheimer's disease pathology, including amyloid-β (Aβ) and tau. Furthermore, we previously reported a relationship between higher levels of physical activity (PA) and lower brain Aβ burden in a human population. The recent advent of tau positron emission tomography (PET) tracers enables us to extend our investigations into the evaluation of the relationship between PA and brain tau burden. Utilizing data from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, we have examined the cross-sectional relationship between habitual PA and PET-quantified tau burden. Forty-three cognitively healthy older adults were categorized into low-moderate PA (LMPA; n = 16) or high PA (HPA; n = 27), based on self-reported PA levels. Tau PET imaging with the AV1451 tracer was conducted on all participants. The LMPA group had significantly higher neocortical tau burden (presented as a z-score; 1.22±1.98), compared to the HPA group (z-score: - 0.28±1.18). The difference between the LMPA and HPA groups was also evident when examining regional tau burden in the temporoparietal cortex and the prefrontal cortex. Our results suggest an association between self-reported PA level and brain tau burden. Future longitudinal and interventional studies utilizing larger samples sizes are vital to further investigate the nature of the relationship between tau and PA.
URI: http://ahro.austin.org.au/austinjspui/handle/1/17739
DOI: 10.3233/JAD-170998
ORCID: 0000-0003-3910-2453
PubMed URL: 29758940
Type: Journal Article
Subjects: Alzheimer’s disease
physical activity
positron emission tomography
tau
Appears in Collections:Journal articles

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