Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/17662
Title: Annexin A1 influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes.
Authors: Tu, Yan;Johnstone, Cameron N;Stewart, Alastair G
Affiliation: Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Melbourne, Australia
Cancer & Inflammation Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
Issue Date: May-2017
EDate: 2017-02-14
Citation: Pharmacological research 2017; 119: 278-288
Abstract: Annexin A1 is a multifunctional protein characterised by its actions in modulating the innate and adaptive immune response. Accumulating evidence of altered annexin A1 expression in many human tumours raises interest in its functional role in cancer biology. In breast cancer, altered annexin A1 expression levels suggest a potential influence on tumorigenic and metastatic processes. However, reports of conflicting results reveal a relationship that is much more complex than first conceptualised. In this review, we explore the diverse actions of annexin A1 on breast tumour cells and various host cell types, including stromal immune and structural cells, particularly in the context of cancer immunoediting.
URI: http://ahro.austin.org.au/austinjspui/handle/1/17662
DOI: 10.1016/j.phrs.2017.02.011
PubMed URL: 28212890
Type: Journal Article
Review
Subjects: Annexin A1
Breast cancer
Cancer immunoediting
Tumour microenvironment
Tumour stroma
Appears in Collections:Journal articles

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