Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/17656
Title: Structural and physiological neurovascular changes in idiopathic Parkinson's disease and its clinical phenotypes.
Authors: Al-Bachari, Sarah;Vidyasagar, Rishma;Emsley, Hedley C A;Parkes, Laura M
Affiliation: Department of Neurology, Salford Royal NHS Foundation Trust, Salford, UK
Division of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Faculty of Health and Medicine, Lancaster University, Lancaster, UK
Anatomy and Neuroscience Department, University of Melbourne, Melbourne, Australia
The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
Department of Neurology, Royal Preston Hospital, Preston, UK
Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Issue Date: Oct-2017
EDate: 2017-01-23
Citation: Journal of cerebral blood flow and metabolism 2017; 37(10): 3409-3421
Abstract: Neurovascular changes are likely to interact importantly with the neurodegenerative process in idiopathic Parkinson's disease (IPD). Markers of neurovascular status (NVS) include white matter lesion (WML) burden and arterial spin labelling (ASL) measurements of cerebral blood flow (CBF) and arterial arrival time (AAT). We investigated NVS in IPD, including an analysis of IPD clinical phenotypes, by comparison with two control groups, one with a history of clinical cerebrovascular disease (CVD) (control positive, CP) and one without CVD (control negative, CN). Fifty-one patients with IPD (mean age 69.0 ± 7.7 years) (21 tremor dominant (TD), 24 postural instability and gait disorder (PIGD) and six intermediates), 18 CP (mean age 70.1 ± 8.0 years) and 34 CN subjects (mean age 67.4 ± 7.6 years) completed a 3T MRI scan protocol including T2-weighted fluid-attenuated inversion recovery (FLAIR) and ASL. IPD patients showed diffuse regions of significantly prolonged AAT, small regions of lower CBF and greater WML burden by comparison with CN subjects. TD patients showed lower WML volume by comparison with PIGD patients. These imaging data thus show altered NVS in IPD, with some evidence for IPD phenotype-specific differences.
URI: http://ahro.austin.org.au/austinjspui/handle/1/17656
DOI: 10.1177/0271678X16688919
PubMed URL: 28112022
Type: Journal Article
Subjects: Magnetic resonance imaging
Parkinson’s disease
arterial spin labelling
cerebral blood flow
cerebrovascular disease
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.