Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/17538
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dc.contributor.authorPatel, Sheila K-
dc.contributor.authorRamchand, Jay-
dc.contributor.authorCrocitti, Vincenzo-
dc.contributor.authorBurrell, Louise M-
dc.date2018-04-27-
dc.date.accessioned2018-05-02T01:03:59Z-
dc.date.available2018-05-02T01:03:59Z-
dc.date.issued2018-04-27-
dc.identifier.citationInternational Journal of Molecular Sciences 2018; 19(5): E1303en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17538-
dc.description.abstractLeft ventricular hypertrophy (LVH) is an independent risk factor for adverse cardiovascular events and is often present in patients with hypertension. Treatment to reduce blood pressure and regress LVH is key to improving health outcomes, but currently available drugs have only modest cardioprotective effects. Improved understanding of the molecular mechanisms involved in the development of LVH may lead to new therapeutic targets in the future. There is now compelling evidence that the transcription factor Kruppel-like factor 15 (KLF15) is an important negative regulator of cardiac hypertrophy in both experimental models and in man. Studies have reported that loss or suppression of KLF15 contributes to LVH, through lack of inhibition of pro-hypertrophic transcription factors and stimulation of trophic and fibrotic signaling pathways. This review provides a summary of the experimental and human studies that have investigated the role of KLF15 in the development of cardiac hypertrophy. It also discusses our recent paper that described the contribution of genetic variants in KLF15 to the development of LVH and heart failure in high-risk patients.en_US
dc.language.isoeng-
dc.subjectKruppel-like factor 15en_US
dc.subjectcardiac hypertrophyen_US
dc.subjectgenetics of left ventricular hypertrophyen_US
dc.subjectheart failureen_US
dc.subjectleft ventricular hypertrophyen_US
dc.titleKruppel-Like Factor 15 Is Critical for the Development of Left Ventricular Hypertrophy.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleInternational Journal of Molecular Sciencesen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.affiliationCardiologyen_US
dc.identifier.doi10.3390/ijms19051303en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-0626-1899en_US
dc.identifier.orcid0000-0003-1863-7539en_US
dc.identifier.pubmedid29702551-
dc.type.austinJournal Article-
dc.type.austinReview-
local.name.researcherBurrell, Louise M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCardiology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
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