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|Title:||Characteristics, incidence and outcome of patients admitted to intensive care unit with Guillain-Barre syndrome in Australia and New Zealand.|
|Authors:||Ancona, Paolo;Bailey, Michael;Bellomo, Rinaldo|
|Affiliation:||Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia|
Department of Anaesthesiology and Intensive Care, Catholic University of Sacred Hearth, "A. Gemelli" University Hospital, Rome, Italy
Australian and New Zealand Intensive Care Research Centre, Monash University School of Public Health and Preventive Medicine, Alfred Hospital, Melbourne, Victoria, Australia
|Citation:||Journal of critical care 2018; 45: 58-64|
|Abstract:||To describe characteristics, incidence and outcome of patients with Guillain-Barre syndrome (GBS) admitted to ICU. We conducted a binational, retrospective, observational, epidemiological study. We compared the baseline characteristics, physiological conditions and outcomes for GBS patients with or without mechanical ventilation (MV) and of survivors and non-survivors. We studied 711 patients admitted to 173 ICUs between 2005 and 2015. We found an increasing proportion of GBS admissions per year (P < 0.03). 237 patients required MV. These patients had higher APACHE III scores (47 vs 31), worse PaO2/FiO2 ratio (P/F 258 v 341), a significantly longer ICU LOS (25 v 4 days) (P < 0.0001, all comparisons) and a greater incidence of pre-ICU cardio-respiratory arrest (6.7% v 1.2%). Similarly, non-survivors were 5-times more likely to have experienced a pre-ICU cardio-respiratory arrest. Overall, ICU and hospital mortality were 3.9% and 6.9%, respectively and increased to 9.7% and 14.3% in the MV group. MV patients remained in hospital for almost 40 days. GBS represents a small but increasing proportion of ICU admissions with one-third of patients receiving MV. Overall in-hospital mortality is relatively low but doubles if MV is needed. These observations provide important prognostic information to clinicians involved in the care of these patients.|
|Appears in Collections:||Journal articles|
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