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Title: Standardized measurement of sensorimotor recovery in stroke trials: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable.
Authors: Kwakkel, Gert;Lannin, Natasha A;Borschmann, Karen;English, Coralie;Ali, Myzoon;Churilov, Leonid;Saposnik, Gustavo;Winstein, Carolee;van Wegen, Erwin Eh;Wolf, Steven L;Krakauer, John W;Bernhardt, Julie
Affiliation: Department of Rehabilitation Medicine, Amsterdam Movement Sciences, Amsterdam Neuroscience, VU University Medical Center Amsterdam, The Netherlands
School of Allied Health, La Trobe University, Melbourne, Australia
The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
University of Newcastle School of Health Sciences and Priority Research Centre for Stroke and Brain Injury, Hunter Medical Research Institute, Australia
Nursing, Midwifery and Allied Health Professions (NMAHP) Research Unit, Glasgow Caledonian University, UK
Stroke Outcomes Research & Center for Virtual Reality Studies ( ); Department of Medicine (Neurology), Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Canada..
Division Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry and Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Department of Rehabilitation Medicine, Division of Physical Therapy, Emory University School of Medicine, Atlanta
VA Center for Visual and Neurocognitive Rehabilitation, Atlanta, GA, USA
Departments of Neurology, Neuroscience, and Physical Medicine & Rehabilitation, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, USA
Department of Occupational Therapy, Alfred Health, Melbourne, Australia
NHMRC Centre of Research Excellence Stroke Rehabilitation and Brain Recovery, Australia
Institutes of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
Issue Date: Jul-2017
Citation: International journal of stroke : official journal of the International Stroke Society 2017; 12(5): 451-461
Abstract: Finding, testing and demonstrating efficacy of new treatments for stroke recovery is a multifaceted challenge. We believe that to advance the field, neurorehabilitation trials need a conceptually rigorous starting framework. An essential first step is to agree on definitions of sensorimotor recovery and on measures consistent with these definitions. Such standardization would allow pooling of participant data across studies and institutions aiding meta-analyses of completed trials, more detailed exploration of recovery profiles of our patients and the generation of new hypotheses. Here, we present the results of a consensus meeting about measurement standards and patient characteristics that we suggest should be collected in all future stroke recovery trials. Recommendations are made considering time post stroke and are aligned with the international classification of functioning and disability. A strong case is made for addition of kinematic and kinetic movement quantification. Further work is being undertaken by our group to form consensus on clinical predictors and pre-stroke clinical data that should be collected, as well as recommendations for additional outcome measurement tools. To improve stroke recovery trials, we urge the research community to consider adopting our recommendations in their trial design.
DOI: 10.1177/1747493017711813
ORCID: 0000-0002-9807-6606
PubMed URL: 28697709
Type: Consensus Development Conference
Journal Article
Subjects: Clinical research
Appears in Collections:Journal articles

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