Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/17420
Title: Associations of Dietary Protein and Fiber Intake with Brain and Blood Amyloid-β.
Authors: Fernando, W M A D Binosha;Rainey-Smith, Stephanie R;Gardener, Samantha L;Villemagne, Victor L;Burnham, Samantha C;Macaulay, S Lance;Brown, Belinda M;Gupta, Veer Bala;Sohrabi, Hamid R;Weinborn, Michael;Taddei, Kevin;Laws, Simon M;Goozee, Kathryn;Ames, David;Fowler, Christopher;Maruff, Paul;Masters, Colin L;Salvado, Olivier;Rowe, Christopher C;Martins, Ralph N
Affiliation: Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
Sir James McCusker Alzheimer's Disease Research Unit, (Hollywood Private Hospital), Perth, WA, Australia
Department of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia
CSIRO Health and Biosecurity/Australian e-Health Research Centre, Australia
School of Psychology and Exercise Science, Murdoch University, Murdoch, WA, Australia
School of Biomedical Sciences, Macquarie University, NSW, Australia
School of Psychological Science, University of Western Australia, Crawley, WA, Australia
Collaborative Genomics Group, Centre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
Cooperative Research Centre for Mental Health, http://www.mentalhealthcrc.com
School of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Australia
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia
McCusker KARVIAH Research Centre, ARV, Sydney, NSW, Australia
Department of Psychiatry, Academic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew, VIC, Australia
National Ageing Research Institute, Parkville, VIC, Australia
Cogstate Ltd., Melbourne, VIC, Australia
Issue Date: 2018
Citation: Journal of Alzheimer's disease : JAD 2018; 61(4): 1589-1598
Abstract: Accumulating evidence suggests a diet high in protein and fiber may confer some protection against Alzheimer's disease (AD). However, no human studies to-date have assessed the relationship between protein and fiber intake, and plasma and brain amyloid-β (Aβ). Consequently, this cross-sectional study, investigated the association of self-reported dietary intakes of protein and fiber, with plasma and brain Aβ burden (n = 541, and n = 162 respectively), in a well-characterized cohort of cognitively normal older adults, drawn from the larger Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. We observed 12.59 and 8.43 higher odds of 'high' brain Aβ burden (PiB PET SUVR≥1.5) if protein intake fell in the lowest and middle tertile, respectively, compared to the highest tertile (p = 0.008; p = 0.013). Thus, in this cohort, the more protein consumed, the less likelihood of 'high' Aβ burden in the brain. No other significant associations were observed. The results of this study highlight the potentially protective impact of high dietary protein intake on brain Aβ burden in older adults, before objective memory decline is apparent. While longitudinal validation is required, these findings may assist in the development of dietary approaches aimed at preventing or delaying AD onset.
URI: http://ahro.austin.org.au/austinjspui/handle/1/17420
DOI: 10.3233/JAD-170742
ORCID: 0000-0003-3910-2453
PubMed URL: 29376865
Type: Journal Article
Subjects: Alzheimer’s disease
PiB PET
amyloid-β
dietary fiber
dietary protein
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.