Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/17278
Title: Canine Mixed Mammary Tumour as a Model for Human Breast Cancer with Osseous Metaplasia.
Authors: Saad, E S;Milley, K M;Al-Khan, A A;Nimmo, J S;Bacci, B;Tayebi, M;Day, M J;Richardson, S J;Danks, J A
Affiliation: School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia..
Australian Specialised Animal Pathology Laboratory, Mulgrave, Victoria, Australia..
School of Veterinary Medicine, University of Surrey, Guildford, UK..
Department of Pathology, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Werribee, Victoria, Australia..
School of Veterinary Sciences, University of Bristol, Langford, UK..
The University of Melbourne, Department of Medicine, Austin Health, Heidelberg, Victoria, Australia.
Issue Date: May-2017
EDate: 2017
Citation: Journal of comparative pathology 2017-05; 156(4): 352-365
Abstract: Canine mixed mammary tumours (CMMTs) and human metaplastic breast carcinomas (HMBCs) share several histopathological features and risk factors. In both species, these tumours display epithelial and stromal components. HMBCs are rare malignant tumours, but CMMTs are one of the most common mammary tumours in dogs and are more often benign than malignant. In this study, benign (n = 88) and malignant (n = 13) CMMTs were characterized using specific antibodies against oestrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, cytokeratin 5/6, cytokeratin AE1/AE3, vimentin, Ki67, E-cadherin and p63. Cartilage and bone matrices associated with benign and malignant CMMTs were characterized using specific antibodies against BMP4, Runx2, Sox9 and osteopontin. The current study suggested that CMMTs are of epithelial origin, but display a myoepithelial-like differentiation. The findings suggest key roles for Sox9, Runx2 and BMP4 in chondrogenesis and bone formation in CMMTs. The high expression of osteopontin in CMMTs appears to be unrelated to tumour malignancy.
URI: http://ahro.austin.org.au/austinjspui/handle/1/17278
DOI: 10.1016/j.jcpa.2017.03.005
PubMed URL: 28449818
Type: Journal Article
Subjects: dog
human breast cancer
immunohistochemistry
mixed mammary tumour
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.