Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/17158
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dc.contributor.authorFealy, Nigel G-
dc.contributor.authorAitken, Leanne-
dc.contributor.authordu Toit, Eugene-
dc.contributor.authorBailey, Michael-
dc.contributor.authorBaldwin, Ian C-
dc.date.accessioned2018-02-22T01:09:09Z-
dc.date.available2018-02-22T01:09:09Z-
dc.date.issued2018-03-
dc.identifier.citationCritical Care and Resuscitation 2018; 20(1): 41-47-
dc.identifier.issn1441-2772-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17158-
dc.description.abstractTo determine if faster blood flow rate (BFR) has an effect on solute maintenance in continuous renal replacement therapy. Prospective randomised controlled trial. 24-bed, single centre, tertiary level intensive care unit. Critically ill adults requiring continuous renal replacement therapy (CRRT). Patients were randomised to receive one of two BFRs: 150 mL/min or 250 mL/min. Changes in urea and creatinine concentrations (percentage change from baseline) and delivered treatment for each 12-hour period were used to assess solute maintenance. 100 patients were randomised, with 96 completing the study (49 patients, 150 mL/min; 47 patients, 250 mL/min). There were a total of 854 12-hour periods (421 periods, 150 mL/min; 433 periods, 250 mL/ min). Mean hours of treatment per 12 hours was 6.3 hours (standard deviation [SD], 3.7) in the 150 mL/min group, and 6.7 hours (SD, 3.9) in the 250 mL/min group (P = 0.6). There was no difference between the two BFR groups for change in mean urea concentration (150 mL/min group, -0.06%; SD, 0.015; v 250 mL/min group, -0.07%; SD, 0.01; P = 0.42) or change in mean creatinine concentration (150 mL/min, -0.05%; SD, 0.01; v 250 mL/min, -0.08%; SD, 0.01; P = 0.18). Independent variables associated with a reduced percentage change in mean serum urea and creatinine concentrations were low haemoglobin levels (-0.01%; SD, 0.005; P = 0.002; and 0.01%; SD, 0.005; P = 0.006, respectively) and less hours treated (-0.023%; SD, 0.001; P = 0.000; and -0.02%; SD, 0.002; P = 0.001, respectively). No effect for bodyweight was found. Faster BFR did not affect solute control in patients receiving CRRT; however, differences in urea and creatinine concentrations were influenced by serum haemoglobin and hours of treatment.-
dc.language.isoeng-
dc.titleEvaluation of urea and creatinine change during continuous renal replacement therapy: effect of blood flow rate.-
dc.typeJournal Article-
dc.identifier.journaltitleCritical Care and Resuscitation-
dc.identifier.affiliationDepartment of Intensive Care Medicine, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationSchool of Nursing and Midwifery, Griffith University, Brisbane, Australia-
dc.identifier.affiliationSchool of Medical Science, Griffith University, Gold Coast, Australia-
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventative Medicine, Melbourne, Australia-
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/29458320-
dc.identifier.pubmedid29458320-
dc.type.austinJournal Article-
local.name.researcherBaldwin, Ian C
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptIntensive Care-
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