Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/17138
Full metadata record
DC FieldValueLanguage
dc.contributor.authorWann, Alysson-
dc.contributor.authorTully, Patrick A-
dc.contributor.authorBarnes, Elizabeth H-
dc.contributor.authorLwin, Zarnie-
dc.contributor.authorJeffree, Rosalind-
dc.contributor.authorDrummond, Katharine J-
dc.contributor.authorGan, Hui K-
dc.contributor.authorKhasraw, Mustafa-
dc.date2018-01-02-
dc.date.accessioned2018-02-07T22:35:18Z-
dc.date.available2018-02-07T22:35:18Z-
dc.date.issued2018-04-
dc.identifier.citationJournal of neuro-oncology 2018; 137(2): 409-415-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17138-
dc.description.abstractStudies looking at the benefit of surgery at first relapse (second surgery) for recurrent glioblastoma were confounded by including patients with varying grades of glioma, performance status and extent of resection. This case-controlled study aims to remove these confounders to assess the survival impact of second surgery in recurrent glioblastoma. Retrospective data on patients with glioblastoma recurrence at two tertiary Australian hospitals from July 2009 to April 2015 was reviewed. Patients who had surgery at recurrence were matched with those who did not undergo surgery at recurrence, based on the extent of their initial resection and age. Overall survival (OS1 assessed from initial diagnosis and OS2 from the date of recurrence) as well as functional outcomes after resection were analysed. There were 120 patients (60 in each institution); median age at diagnosis was 56 years. Median OS1 was 14 months (95% CI 11.5-15.7) versus 22 months (95% CI 18-25) in patients who did not undergo second surgery and those with surgery at recurrence. OS2 was improved by second surgery (4.7 vs 9.6, HR 0.52, 95% CI 0.38-0.72, P < 0.001), and by chemotherapy, given at recurrence, (HR 0.47, 95% CI 0.24-0.92, P = 0.03). After second surgery, 80% did not require rehabilitation and 61% were independently mobile. Second surgery for recurrent glioblastoma was associated with a survival advantage. Chemotherapy independent of surgery, also improved survival. Functional outcomes were encouraging. More research is required in the era of improved surgical techniques and new antineoplastic therapies.-
dc.language.isoeng-
dc.subjectChemotherapy-
dc.subjectGlioblastoma recurrence-
dc.subjectSecond surgery-
dc.subjectSurvival-
dc.titleOutcomes after second surgery for recurrent glioblastoma: a retrospective case-control study.-
dc.typeJournal Article-
dc.identifier.journaltitleJournal of neuro-oncology-
dc.identifier.affiliationOlivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationThe Cooperative Trials Group for Neuro-Oncology (COGNO), University of Sydney, Sydney, NSW, Australiaen
dc.identifier.affiliationSchool of Medicine, University of Queensland, Brisbane, QLD, Australiaen
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationSchool of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationNational Health and Medical Council Clinical Trials Centre, University of Sydney, Sydney, NSW, Australiaen
dc.identifier.affiliationDepartment of Surgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia-
dc.identifier.affiliationRoyal Brisbane Hospital, Brisbane, QLD, Australia-
dc.identifier.affiliationDepartment of Medicine, Melbourne University, Melbourne, Victoria, Australia-
dc.identifier.affiliationSchool of Medicine, University of Notre Dame, Sydney, NSW, Australia-
dc.identifier.doi10.1007/s11060-017-2731-2-
dc.identifier.orcid0000-0001-9536-316X-
dc.identifier.pubmedid29294233-
dc.type.austinJournal Article-
local.name.researcherGan, Hui K
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptMedical Oncology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

18
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.