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|Title:||Elucidating the Pharmacokinetics/Pharmacodynamics of Aerosolized Colistin against Multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Mouse Lung Infection Model|
|Authors:||Lin, Yu-Wei;Zhou, Qi Tony;Han, Mei-Ling;Chen, Ke;Onufrak, Nikolas J;Wang, Jiping;Turnidge, John D;Howden, Benjamin P;Forrest, Alan;Chan, Hak-Kim;Li, Jian|
|Citation:||Antimicrobial Agents and Chemotherapy 2017; online first: 11 December|
|Abstract:||Pharmacokinetics/pharmacodynamics (PK/PD) of aerosolized colistin was investigated against Acinetobacter baumannii and Klebsiella pneumoniae over 24 h in a neutropenic mouse lung infection model. Dose fractionation studies were performed over 2.64 to 23.8 mg/kg/day, and the data were fitted to a sigmoid inhibitory model. AUC/MIC in the epithelial lining fluid was the most predictive PK/PD index for aerosolized colistin against both pathogens. Our study provides important pharmacological information for optimizing aerosolized colistin.|
|Appears in Collections:||Journal articles|
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