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Title: Elucidating the Pharmacokinetics/Pharmacodynamics of Aerosolized Colistin against Multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Mouse Lung Infection Model
Authors: Lin, Yu-Wei;Zhou, Qi Tony;Han, Mei-Ling;Chen, Ke;Onufrak, Nikolas J;Wang, Jiping;Turnidge, John D;Howden, Benjamin P;Forrest, Alan;Chan, Hak-Kim;Li, Jian
Issue Date: 11-Dec-2017
EDate: 2017-12-11
Citation: Antimicrobial Agents and Chemotherapy 2017; online first: 11 December
Abstract: Pharmacokinetics/pharmacodynamics (PK/PD) of aerosolized colistin was investigated against Acinetobacter baumannii and Klebsiella pneumoniae over 24 h in a neutropenic mouse lung infection model. Dose fractionation studies were performed over 2.64 to 23.8 mg/kg/day, and the data were fitted to a sigmoid inhibitory model. AUC/MIC in the epithelial lining fluid was the most predictive PK/PD index for aerosolized colistin against both pathogens. Our study provides important pharmacological information for optimizing aerosolized colistin.
DOI: 10.1128/AAC.01790-17
PubMed URL:
Type: Journal Article
Appears in Collections:Journal articles

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