Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16948
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dc.contributor.authorWeinberg, Laurence-
dc.contributor.authorChiam, Elizabeth-
dc.contributor.authorHooper, James-
dc.contributor.authorLiskaser, Frank-
dc.contributor.authorHawkins, Angela Kim-
dc.contributor.authorMassie, Denise-
dc.contributor.authorEllis, Andrew-
dc.contributor.authorTan, Chong O-
dc.contributor.authorStory, David A-
dc.contributor.authorBellomo, Rinaldo-
dc.date2017-11-01-
dc.date.accessioned2017-11-21T01:12:11Z-
dc.date.available2017-11-21T01:12:11Z-
dc.date.issued2018-05-
dc.identifier.citationPerfusion 2018; 33(4): 310-319en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16948-
dc.description.abstractBACKGROUND: The mechanisms of acid-base changes during cardiopulmonary bypass (CPB) remain unclear. We tested the hypothesis that, when used as CPB pump prime solutions, Plasma-Lyte 148 (PL) and Hartmann's solution (HS) have differential mechanisms of action in their contribution to acid-base changes. METHODS: We performed a prospective, double-blind, randomized trial in adult patients undergoing elective cardiac surgery with CPB. Participants received a CPB prime solution of 2000 mL, with either PL or HS. The primary endpoint was the standard base excess (SBE) value measured at 60 minutes after full CPB flows (SBE60min). Secondary outcomes included changes in SBE, pH, chloride, sodium, lactate, gluconate, acetate, strong ion difference and strong ion gap at two (T2min), five (T5min), ten (T10min), thirty (T30min) and sixty (T60min) minutes on CPB. The primary outcome was measured using a two-tailed Welch's t-test. Repeated measures ANOVA was used to test for differences between time points. RESULTS: Twenty-five participants were randomized to PL and 25 to HS. Baseline characteristics, EURO and APACHE scores, biochemistry, hematology and volumes of cardioplegia were similar. Mean (SD) SBE at T60min was -1.3 (1.4) in the PL group and -0.1 (2.7) in the HS group; p=0.55. No significant differences in SBE between the groups was observed during the first 60 minutes (p=0.48). During CPB, there was hyperacetatemia and hypergluconatemia in the PL group and hyperlactatemia and hyperchloremia in the HS group. No significant difference between the groups in plasma bicarbonate levels and total weak acid levels were found. Complications and intensive care unit and hospital length of stays were similar. CONCLUSIONS: During CPB, PL and HS did not cause a significant metabolic acidosis. There was hyperacetatemia and hypergluconatemia with PL and hyperchloremia and hyperlactatemia with HS. These physiochemical effects appear clinically innocuous.en_US
dc.subjectHartmann’s solutionen_US
dc.subjectPlasma-Lyte148en_US
dc.subjectacid baseen_US
dc.subjectanesthesiaen_US
dc.subjectcardiac primeen_US
dc.subjectcardiopulmonary bypassen_US
dc.subjectcrystalloiden_US
dc.titlePlasma-Lyte 148 vs. Hartmann's solution for cardiopulmonary bypass pump prime: a prospective double-blind randomized trialen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitlePerfusionen_US
dc.identifier.affiliationDepartment of Anesthesia, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Clinical Pharmacology and Therapeutics, Austin Hospital, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationAnesthesia, Perioperative and Pain Medicine Unit, Melbourne Medical School, University of Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Intensive Care, The University of Melbourne, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/29144182en_US
dc.identifier.doi10.1177/0267659117742479en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-7403-7680en_US
dc.identifier.orcid0000-0002-6479-1310en_US
dc.identifier.orcid0000-0002-1650-8939en_US
dc.identifier.pubmedid29144182-
dc.type.austinJournal Articleen_US
local.name.researcherBellomo, Rinaldo
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptAnaesthesia-
crisitem.author.deptAnaesthesia-
crisitem.author.deptAnaesthesia-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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