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Title: Inhibiting system xC− and glutathione biosynthesis – a potential Achilles' heel in mutant-p53 cancers
Authors: Clemons, Nicholas J;Liu, David S;Duong, Cuong P;Phillips, Wayne A
Issue Date: 5-Jul-2017
Citation: Molecular & Cellular Oncology 2017; 4(5): e1344757
Abstract: Effective therapeutic strategies to target mutant tumor protein p53 (TP53, best known as p53) cancers remain an unmet medical need. We found that mutant p53 impairs the function of nuclear factor (erythroid-derived 2)-like 2 (NFE2L2, commonly known as NRF2), suppresses solute carrier family 7 member 11 (SLC7A11) expression, and diminishes cellular glutamate/cystine exchange. This decreases glutathione biosynthesis, resulting in redox imbalance. Mutant p53 tumors are thus inherently susceptible to further perturbations of the SLC7A11/glutathione axis.
DOI: 10.1080/23723556.2017.1344757
PubMed URL:
Type: Journal Article
Subjects: APR-246
glutathione (GSH)
reactive oxygen species (ROS)
system xC−
Appears in Collections:Journal articles

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