Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16830
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dc.contributor.authorLee, Sophie Nen_US
dc.contributor.authorChakrabarty, Basuen_US
dc.contributor.authorWittmer, Braden_US
dc.contributor.authorPapargiris, Melissaen_US
dc.contributor.authorRyan, Andrewen_US
dc.contributor.authorFrydenberg, Marken_US
dc.contributor.authorLawrentschuk, Nathanen_US
dc.contributor.authorMiddendorff, Ralfen_US
dc.contributor.authorRisbridger, Gail Pen_US
dc.contributor.authorEllem, Stuart Jen_US
dc.contributor.authorExintaris, Bettyen_US
dc.date.accessioned2017-09-07T01:50:30Z-
dc.date.available2017-09-07T01:50:30Z-
dc.date.issued2017-08-31en_US
dc.identifier.citationScientific Reports 2017; 7(1): 10150-
dc.identifier.govdoc28860509-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16830-
dc.description.abstractLower urinary tract symptoms (LUTS) due to Benign Prostatic Hyperplasia (BPH) are highly prevalent in older men, having a profound impact on patient quality of life. Current therapeutics for BPH/LUTS target neurogenic smooth muscle tone, but response is unpredictable and many patients fail to respond. Spontaneous myogenic tone is another component of smooth muscle contractility that is uncharacterized in human prostate. To better understand and improve the predictability of patient response, we defined myogenic contractility using human prostate specimens and examined the effect of existing therapeutics. We show that myogenic activity is present in the human prostate with the frequency of contractions in transition zone (TZ) specimens from BPH diagnosed patients approximately 160% greater than matched controls. α1-adrenoreceptor antagonists (Tamsulosin) and PDE5 inhibitors (Sildenafil) both significantly reduced myogenic contractile parameters, including frequency, with notable interpatient variability. Tamsulosin was more effective in older patients (R(2) = 0.36, p < 0.01) and men with larger prostate volumes (R(2) = 0.41, p < 0.05), while Sildenafil was more effective in younger men (R(2) = 0.45, p < 0.05). As myogenic tone is significantly increased in BPH, therapeutics targeting this mechanism used with reference to patient characteristics could improve clinical outcomes and better predict patient response.en_US
dc.language.isoengen_US
dc.titleAge related differences in responsiveness to sildenafil and tamsulosin are due to myogenic smooth muscle tone in the human prostateen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleScientific Reports-
dc.identifier.affiliationDepartment of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia-
dc.identifier.affiliationDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Melbourne, Victoria, Australia-
dc.identifier.affiliationTissuePath, Melbourne, Victoria, Australia-
dc.identifier.affiliationDepartment of Surgery, Monash University, Melbourne, Victoria, Australia-
dc.identifier.affiliationAustralian Urology Associates, Melbourne, Victoria, Australia-
dc.identifier.affiliationDepartment of Surgery, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia-
dc.identifier.affiliationJustus-Liebig-University Giessen, Institute of Anatomy and Cell Biology, Giessen, Germany-
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28860509-
dc.identifier.doi10.1038/s41598-017-07861-x-
dc.identifier.orcid0000-0001-8553-5618-
dc.type.austinJournal Articleen_US
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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