Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16827
Title: Neutrophils, G-CSF and their contribution to breast cancer metastasis
Authors: Mouchemore, Kellie A;Anderson, Robin L;Hamilton, John A
Issue Date: 21-Aug-2017
EDate: 2017-08-21
Citation: The FEBS Journal 2017; online first: 21 August
Abstract: Evidence is mounting for a role for neutrophils in breast cancer progression to metastasis. However, the role of G-CSF in neutrophil biology in a cancer setting remains to be defined. Herein we discuss the most recent clinical and experimental evidence for neutrophils and G-CSF in the promotion of metastasis, demonstrating a potential mechanistic link between them. Understanding this link is imperative both for the development of diagnostic tests and for therapies targeting neutrophils to improve the treatment of breast cancer patients with, or at risk of developing metastatic disease. Since a high neutrophil to lymphocyte ratio in patients predicts poor outcome, while mild neutropenia predicts an improved outcome, we urge caution in the use of G-CSF in neutrophil recovery following chemotherapy as there is increasing evidence in preclinical models that G-CSF can promote metastasis.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16827
DOI: 10.1111/febs.14206
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/28834401
Type: Journal Article
Subjects: Breast cancer
G-CSF
Metastasis
Neutrophil extracellular traps
Neutrophils
Therapy
Appears in Collections:Journal articles

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