Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16800
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dc.contributor.authorCamillo, Carlos A-
dc.contributor.authorLanger, Daniel-
dc.contributor.authorOsadnik, Christian R-
dc.contributor.authorPancini, Lisa-
dc.contributor.authorDemeyer, Heleen-
dc.contributor.authorBurtin, Chris-
dc.contributor.authorGosselink, Rik-
dc.contributor.authorDecramer, Marc-
dc.contributor.authorJanssens, Wim-
dc.contributor.authorTroosters, Thierry-
dc.date.accessioned2017-08-17T23:15:06Z-
dc.date.available2017-08-17T23:15:06Z-
dc.date.issued2016-10-26-
dc.identifier.citationInternational Journal of COPD 2016; 11(1): 2671-2679en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16800-
dc.description.abstractThe impact of rehabilitation-induced changes in 6-minute walk distance (6MWD) on the survival of patients with chronic obstructive pulmonary disease (COPD) has not been fully elucidated. This study sought to determine the association of baseline 6MWD and its changes after pulmonary rehabilitation (PR) with 5-year survival in patients with COPD. Patients who were referred to a 12-week outpatient PR program were followed up for 5 years postcompletion, and survival status was verified. Survival was analyzed according to four groups based upon initial 6MWD (6MWDi) and its changes (Δ6MWD) after PR (Group 1: 6MWDi ≥350 m and Δ6MWD ≥30 m; Group 2: 6MWDi ≥350 m and Δ6MWD <30 m; Group 3: 6MWDi <350 m and Δ6MWD ≥30 m; and Group 4: 6MWDi <350 m and Δ6MWD <30 m) via Kaplan–Meier analysis and log rank test. Cox regression was performed to identify possible confounders of mortality estimates. In total, 423 patients (with mean ± standard deviation of forced expiratory volume in the first second [FEV1] 43±16% predicted, age 65±8 years, and 6WMDi 381±134 m) underwent PR between 1999 and 2010. Survival rates decreased progressively from Group 1 to Group 4 (Group 1, 81%; Group 2, 69%; Group 3, 47%; Group 4, 27%; log rank test, P<0.05). 6MWDi ≥350 m (hazard ratio [HR] 0.39 [95% confidence interval {CI} 0.30–0.50]) and Δ6MWD ≥30 m (HR 0.66 [95% CI 0.51–0.85]) were strongly and independently associated with survival. Compared with Group 1, mortality risks progressively increased in Group 2 (HR 1.36 [95% CI 0.92–2.00]; not significant), Group 3 (HR 1.90 [95% CI 1.28–2.84]; P=0.001), and Group 4 (HR 3.28 [95% CI 2.02–5.33]; P,0.0001). Both poor 6MWD and lack of improvement >30 m after PR are associated with worse 5-year survival in patients with COPD.en_US
dc.subjectPulmonary diseaseen_US
dc.subjectChronic obstructiveen_US
dc.subjectExercise trainingen_US
dc.subjectMortalityen_US
dc.subject6-minute walk testen_US
dc.subjectMinimally important differenceen_US
dc.titleSurvival after pulmonary rehabilitation in patients with COPD: impact of functional exercise capacity and its changesen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleInternational Journal of COPDen_US
dc.identifier.affiliationInstitute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Rehabilitation Sciences, KU Leuven, Leuven, Belgiumen_US
dc.identifier.affiliationUniversity Hospital Leuven, Respiratory Division and Rehabilitation, Leuven, Belgiumen_US
dc.identifier.affiliationDepartment of Physiotherapy, Monash University, Melbourne, VIC, Australiaen_US
dc.identifier.affiliationMonash Health, Monash Lung and Sleep, Melbourne, VIC, Australiaen_US
dc.identifier.affiliationHasselt University, Rehabilitation Research Centre, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Diepenbeek, Belgiumen_US
dc.identifier.doi10.2147/COPD.S113450en_US
dc.type.contentTexten_US
dc.identifier.pubmedid27822029-
dc.type.austinJournal Articleen_US
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
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