Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16798
Title: Sensory detection of threshold intensity resistive loads in severe obstructive sleep apnoea
Authors: Ruehland, Warren R;Rochford, Peter D;Pierce, Robert J;Webster, Kate E;Trinder, John A;Jordan, Amy S;O’Donoghue, Fergal J
Issue Date: Feb-2017
EDate: 2016-11-09
Citation: Respiratory Physiology & Neurobiology 2017; 236: 29-41
Abstract: Respiratory related evoked potentials (RREPs) were used to investigate whether sensory detection of small mid-inspiratory resistive loads (≈1.2-6.2 cmH2OL-1s), delivered during wakefulness, was impaired in obstructive sleep apnoea (OSA). It was reasoned that impaired detection of minor airway patency challenge may lead to difficult-to-remedy further collapse. There was a significant reduction in OSA (n=16) vs. control (n=17) participants in the slope of the relationship between the P1 RREP component amplitude, which reflects arrival of somatosensory information at the cortex, and stimulus intensity, expressed as change in epiglottic pressure (mean [95% confidence intervals]: -0.50 [-0.97, -0.03] vs. -1.78 [-2.54, -1.02]; P=0.004), suggesting a reduction in sensitivity to small respiratory loads. However there was no significant difference in sensitivity after background Pepi was taken into account (P=0.268). Additionally, there were no significant group differences in the threshold of the P1 amplitude/stimulus intensity relationship, or in the P1 latency. These results indicate a reduced sensitivity to detection of small upper airway negative pressure stimuli in OSA related to a reduction in mechanoreceptor activation (likely related to increased airway resistance in OSA vs. controls; P=0.002) rather than defective mechanosensory function.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16798
DOI: 10.1016/j.resp.2016.10.014
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/27836649
Type: Journal Article
Subjects: Airway resistance
Load detection
Negative airway pressure
Obstructive sleep apnoea
Respiratory related evoked potential (RREP)
Respiratory sensation
Appears in Collections:Journal articles

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