Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16777
Title: A pilot study of peripheral blood BDCA-1 (CD1c) positive dendritic cells pulsed with NY-ESO-1 ISCOMATRIX™ adjuvant
Authors: Davis, Ian D;Quirk, Juliet;Morris, Leone;Seddon, Lauren;Tai, Tsin Yee;Whitty, Genevieve;Cavicchiolo, Tina;Ebert, Lisa;Jackson, Heather;Browning, Judy;MacGregor, Duncan;Wittke, Frederick;Winkels, Gregor;Alex, Regina;Miloradovic, Lena;Maraskovsky, Eugene;Chen, Weisan;Cebon, Jonathan S
Issue Date: Mar-2017
EDate: 2017-02-10
Citation: Immunotherapy 2017; 9(3): 249-259
Abstract: Pilot clinical trial of NY-ESO-1 (ESO) protein in ISCOMATRIX™ adjuvant pulsed onto peripheral blood dendritic cells (PBDC), to ascertain feasibility, evaluate toxicity and assess induction of ESO-specific immune responses. PATIENTS & METHODS: Eligible participants had resected cancers expressing ESO or LAGE-1 and were at high risk of relapse. PBDC were produced using CliniMACS®plus, with initial depletion of CD1c+ B cells followed by positive selection of CD1c+ PBDC. Patients received three intradermal vaccinations of ESO/IMX-pulsed PBDC at 4-week intervals. RESULTS: The process was feasible and safe. No vaccine-induced immune responses were detected. Assays of immunomodulatory cells did not correlate with outcomes. One patient had a long lasting complete remission. CONCLUSION: This method was feasible and safe but was minimally immunogenic.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16777
DOI: 10.2217/imt-2016-0132
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/28183192
Type: Journal Article
Subjects: ISCOMATRIX™ adjuvant
NY-ESO-1
Antigens
Clinical trial
Dendritic cells
Type of Clinical Study or Trial: Clinical Trial
Appears in Collections:Journal articles

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