Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16754
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dc.contributor.authorThijs, Vincent N-
dc.contributor.authorGrittner, Ulrike-
dc.contributor.authorFazekas, Franz-
dc.contributor.authorMcCabe, Dominick JH-
dc.contributor.authorGiese, Anne-Katrin-
dc.contributor.authorKessler, Christof-
dc.contributor.authorMartus, Peter-
dc.contributor.authorNorrving, Bo-
dc.contributor.authorRingelstein, Erich Bernd-
dc.contributor.authorSchmidt, Reinhold-
dc.contributor.authorTanislav, Christian-
dc.contributor.authorPutaala, Jukka-
dc.contributor.authorTatlisumak, Turgut-
dc.contributor.authorvon Sarnowski, Bettina-
dc.contributor.authorRolfs, Arndt-
dc.contributor.authorEnzinger, Christian-
dc.contributor.authorStroke in Fabry (SIFAP1) Investigators-
dc.date2017-07-28-
dc.date.accessioned2017-08-02T05:23:44Z-
dc.date.available2017-08-02T05:23:44Z-
dc.date.issued2017-07-28-
dc.identifier.citationStroke 2017; 48(9): 2361-2367en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16754-
dc.description.abstractWe evaluated whether basilar dolichoectasia is associated with markers of cerebral small vessel disease in younger transient ischemic attack and ischemic stroke patients. METHODS: We used data from the SIFAP1 study (Stroke in Young Fabry Patients), a large prospective, hospital-based, screening study for Fabry disease in young (<55 years) transient ischemic attack/stroke patients in whom detailed clinical data and brain MRI were obtained, and stroke subtyping with TOAST classification (Trial of ORG 10172 in Acute Stroke Treatment) was performed. RESULTS: Dolichoectasia was found in 508 of 3850 (13.2%) of patients. Dolichoectasia was associated with older age (odds ratio per decade, 1.26; 95% confidence interval, 1.09-1.44), male sex (odds ratio, 1.96; 95% confidence interval, 1.59-2.42), and hypertension (odds ratio, 1.39; 95% confidence interval, 1.13-1.70). Dolichoectasia was more common in patients with small infarctions (33.9% versus 29.8% for acute lesions, P=0.065; 29.1% versus 16.5% for old lesions, P<0.001), infarct location in the brain stem (12.4% versus 6.9%, P<0.001), and in white matter (27.8% versus 21.1%, P=0.001). Microbleeds (16.3% versus 4.7%, P=0.001), higher grades of white matter hyperintensities (P<0.001), and small vessel disease subtype (18.1% versus 12.4%, overall P for differences in TOAST (P=0.018) were more often present in patients with dolichoectasia. CONCLUSIONS: Dolichoectasia is associated with imaging markers of small vessel disease and brain stem localization of acute and old infarcts in younger patients with transient ischemic attack and ischemic stroke. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00414583.en_US
dc.subjectFabry diseaseen_US
dc.subjectHypertensionen_US
dc.subjectInfarctionen_US
dc.subjectStrokeen_US
dc.subjectWhite matteren_US
dc.titleDolichoectasia and small vessel disease in young patients with transient ischemic attack and strokeen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleStrokeen_US
dc.identifier.affiliationStroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationCenter for Stroke Research and Department of Biostatistics and Clinical Epidemiology, Charité - University Medical Centre Berlin, Germanyen_US
dc.identifier.affiliationDepartment of Neurology, Medical University of Graz, Austriaen_US
dc.identifier.affiliationDivision of Neuroradiology, Department of Radiology, Medical University of Graz, Austriaen_US
dc.identifier.affiliationDepartment of Neurology, The Adelaide and Meath Hospital, Incorporating the National Children's Hospital, Dublin, Republic of Irelanden_US
dc.identifier.affiliationDepartment of Clinical Neurosciences, Royal Free Campus, UCL Institute of Neurology, London, United Kingdomen_US
dc.identifier.affiliationAcademic Unit of Neurology, School of Medicine, Trinity College Dublin, Irelanden_US
dc.identifier.affiliationAlbrecht-Kossel-Institute for Neuroregeneration (AKos) Centre for Mental Health Disease University of Rostock, Germanyen_US
dc.identifier.affiliationDepartment of Neurology, University Medicine Greifswald, Ernst-Moritz-Arndt-University Greifswald, Germanyen_US
dc.identifier.affiliationInstitut für Klinische Epidemiologie und Angewandte Biometrie (IKEaB), Tübingen, Germanyen_US
dc.identifier.affiliationDepartment of Clinical Sciences Neurology, Lund University, Swedenen_US
dc.identifier.affiliationWilhelms University of Muenster, Germanyen_US
dc.identifier.affiliationDepartment of Neurology, Justus Liebig University Giessen, Germanyen_US
dc.identifier.affiliationDepartment of Neurology, Helsinki University Central Hospital, Finlanden_US
dc.identifier.affiliationClinical Neurosciences, University of Helsinki, Finlanden_US
dc.identifier.affiliationInstitute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Swedenen_US
dc.identifier.affiliationDepartment of Neurology, Sahlgrenska University Hospital, Gothenburg, Swedenen_US
dc.type.studyortrialCohort Studyen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28754833en_US
dc.identifier.doi10.1161/STROKEAHA.117.017406en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-6614-8417en_US
dc.type.austinJournal Articleen_US
local.name.researcherThijs, Vincent N
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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