Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16719
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dc.contributor.authorPardo, Fernando-
dc.contributor.authorSangro, Bruno-
dc.contributor.authorLee, Rheun-Chuan-
dc.contributor.authorManas, Derek-
dc.contributor.authorJeyarajah, Rohan-
dc.contributor.authorDonckier, Vincent-
dc.contributor.authorMaleux, Geert-
dc.contributor.authorPinna, Antonio D-
dc.contributor.authorBester, Lourens-
dc.contributor.authorMorris, David L-
dc.contributor.authorIannitti, David-
dc.contributor.authorChow, Pierce K-
dc.contributor.authorStubbs, Richard-
dc.contributor.authorGow, Paul J-
dc.contributor.authorMasi, Gianluca-
dc.contributor.authorFisher, Kevin T-
dc.contributor.authorLau, Wan Y-
dc.contributor.authorKouladouros, Konstantinos-
dc.contributor.authorKatsanos, Georgios-
dc.contributor.authorErcolani, Giorgio-
dc.contributor.authorRotellar, Fernando-
dc.contributor.authorBilbao, José I-
dc.contributor.authorSchoen, Michael-
dc.date2017-06-27-
dc.date.accessioned2017-07-13T01:33:31Z-
dc.date.available2017-07-13T01:33:31Z-
dc.date.issued2017-06-27-
dc.identifier.citationAnnals of Surgical Oncology 2017; 24(9): 2468-2473en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16719-
dc.description.abstractBACKGROUND: Reports show that selective internal radiation therapy (SIRT) may downsize inoperable liver tumors to resection or transplantation, or enable a bridge-to-transplant. A small-cohort study found that long-term survival in patients undergoing resection following SIRT appears possible but no robust studies on postsurgical safety outcomes exist. The Post-SIR-Spheres Surgery Study was an international, multicenter, retrospective study to assess safety outcomes of liver resection or transplantation following SIRT with yttrium-90 (Y-90) resin microspheres (SIR-Spheres®; Sirtex). METHODS: Data were captured retrospectively at participating SIRT centers, with Y-90 resin microspheres, surgery (resection or transplantation), and follow-up for all eligible patients. Primary endpoints were perioperative and 90-day postoperative morbidity and mortality. Standard statistical methods were used. RESULTS: The study included 100 patients [hepatocellular carcinoma: 49; metastatic colorectal cancer (mCRC): 30; cholangiocarcinoma, metastatic neuroendocrine tumor, other: 7 each]; 36% of patients had one or more lines of chemotherapy pre-SIRT. Sixty-three percent of patients had comorbidities, including hypertension (44%), diabetes (26%), and cardiopathy (16%). Post-SIRT, 71 patients were resected and 29 received a liver transplant. Grade 3+ peri/postoperative complications and any grade of liver failure were experienced by 24 and 7% of patients, respectively. Four patients died <90 days postsurgery; all were trisectionectomies (mCRC: 3; cholangiocarcinoma: 1) and typically had one or more previous chemotherapy lines and presurgical comorbidities. CONCLUSIONS: In 100 patients undergoing liver surgery after receiving SIRT, mortality and complication rates appeared acceptable given the risk profile of the recruited patients.en_US
dc.titleThe Post-SIR-Spheres Surgery Study (P4S): retrospective analysis of safety following hepatic resection or transplantation in patients previously treated with selective internal radiation therapy with yttrium-90 resin microspheresen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleAnnals of Surgical Oncologyen_US
dc.identifier.affiliationHPB and Transplant Surgery, Clinica Universidad de Navarra, IDISNA, Pamplona, Navarra, Spainen_US
dc.identifier.affiliationLiver Unit, Clinica Universidad de Navarra, IDISNA, CIBEREHD, Pamplona, Navarra, Spainen_US
dc.identifier.affiliationRadiology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwanen_US
dc.identifier.affiliationInstitute of Transplantation, University of Newcastle Upon Tyne, Newcastle Upon Tyne, UKen_US
dc.identifier.affiliationNewcastle NHS Trust, Newcastle Upon Tyne, UKen_US
dc.identifier.affiliationSurgical Oncology, Methodist Dallas Medical Center, Dallas, TX, USAen_US
dc.identifier.affiliationDepartment of Surgery, Institut Jules Bordet, Université Libre de Bruxelles and Centre de Chirurgie Hépato-Biliaire de l'ULB, Brussels, Belgiumen_US
dc.identifier.affiliationRadiology, University Hospitals Leuven, Louvain, Belgiumen_US
dc.identifier.affiliationHepatobiliary and Transplant Surgery, S. Orsola-Malpighi, University of Bologna, Bologna, Italyen_US
dc.identifier.affiliationInterventional Radiology, St Vincent's Hospital, Sydney, NSW, Australiaen_US
dc.identifier.affiliationDepartment of Surgery, St George Hospital, University of New South Wales, Kogarah, NSW, Australiaen_US
dc.identifier.affiliationHPB Surgery, Carolinas Medical Center, Charlotte, NC, USAen_US
dc.identifier.affiliationSurgical Oncology, National Cancer Center, Singapore, Singaporeen_US
dc.identifier.affiliationHepatobiliary Surgery, Wakefield Clinic, Wellington, New Zealanden_US
dc.identifier.affiliationVictorian Liver Transplant Uniten_US
dc.identifier.affiliationMedical Oncology, Ospedale Santa Chiara, Pisa, Italyen_US
dc.identifier.affiliationDepartment of Surgery, Saint Francis Hospital, Tulsa, OK, USAen_US
dc.identifier.affiliationFaculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, Hong Kongen_US
dc.identifier.affiliationKlinikum Karlsruhe, Karlsruhe, Germanyen_US
dc.identifier.affiliationDepartment of Abdominal Surgery, Hôpital Erasme, Université Libre de Bruxelles and Centre de Chirurgie Hépato-Biliaire de l'ULB, Brussels, Belgiumen_US
dc.identifier.affiliationHepatobiliary and Transplant Surgery, Sant'Orsola Hospital, University of Bologna, Bologna, Italyen_US
dc.identifier.affiliationInterventional Radiology, Clinica Universidad de Navarra, IDISNA, Pamplona, Navarra, Spainen_US
dc.identifier.affiliationGastroenterology and Hepatologyen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28653161en_US
dc.identifier.doi10.1245/s10434-017-5950-zen_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
local.name.researcherGow, Paul J
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
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