Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16686
Title: Herpes simplex virus-2 transmission following solid organ transplantation: Donor-derived infection and transplantation from prior organ recipients
Authors: Macesic, Nenad;Abbott, Ian J;Kaye, Matthew;Druce, Julian;Glanville, Allan R;Gow, Paul J;Hughes, Peter D;Korman, Tony M;Mulley, William R;O'Connell, Phillip J;Opdam, Helen;Paraskeva, Miranda;Pitman, Matthew C;Setyapranata, Stella;Rawlinson, William D;Johnson, Paul D R
Issue Date: Oct-2017
EDate: 2017-06-15
Citation: Transplant Infectious Disease 2017; 19(5): e12739
Abstract: BACKGROUND: Owing to limited availability of donor organs, previous solid organ transplant (SOT) recipients are increasingly considered as potential organ donors. We report donor-derived transmission of herpes simplex virus type-2 (HSV-2) to two clusters of SOT recipients with transmission from the original donor and an HSV-2-infected recipient who subsequently became a donor. METHODS: We reviewed medical records of the donors and recipients in both clusters. Pre-transplant serology and virological features of HSV-2 were characterized. Genotyping of HSV-2 isolates to determine potential for donor transmission of HSV-2 through transplantation of organs from prior organ recipients was performed. RESULTS: A kidney-pancreas recipient died day 9 post transplant. Following confirmation of brain death, the lungs and recently transplanted kidney were donated to two further recipients. The liver was not retrieved, but biopsy confirmed HSV-2 infection. Testing on the original donor showed negative HSV-2 polymerase chain reaction and HSV immunoglobulin (Ig)M, but positive HSV-2 IgG. The liver recipient from the original donor developed HSV-2 hepatitis and cutaneous infection that responded to treatment with intravenous acyclovir. In the second cluster, lung and kidney recipients both developed HSV-2 viremia that was successfully treated with antiviral therapy. Genotyping of all HSV-2-positive samples showed 100% sequence homology for three recipients. CONCLUSIONS: Donor-derived HSV infection affected two clusters of recipients because of transplantation of organs from a prior organ recipient. HSV should be considered as a possible cause of illness in febrile SOT recipients in the immediate post-transplant period and may cause disseminated disease and re-infection in HSV-2-seropositive recipients. Testing of HSV serology and prophylaxis may be considered in SOT recipients not receiving cytomegalovirus prophylaxis.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16686
DOI: 10.1111/tid.12739
ORCID: 0000-0002-7905-628X
0000-0002-6155-8353
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/28618165
Type: Journal Article
Subjects: Allograft re-use
Donor-derived infection
Hepatitis herpes simplex virus
Transplantation
Appears in Collections:Journal articles

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