Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16609
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dc.contributor.authorTan, Sven-Jean-
dc.contributor.authorCrosthwaite, Amy-
dc.contributor.authorLangsford, David-
dc.contributor.authorObeysekere, Varuni-
dc.contributor.authorIerino, Frank L-
dc.contributor.authorRoberts, Matthew A-
dc.contributor.authorHughes, Peter D-
dc.contributor.authorHewitson, Tim D-
dc.contributor.authorDwyer, Karen M-
dc.contributor.authorToussaint, Nigel D-
dc.date2017-03-05-
dc.date.accessioned2017-03-19T23:11:49Z-
dc.date.available2017-03-19T23:11:49Z-
dc.date.issued2017-03-05-
dc.identifier.citationTransplant International 2017; online first: 5 Marchen_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16609-
dc.description.abstractKlotho is predominantly expressed in the kidney and reported to have antioxidant and antifibrotic properties. Soluble Klotho (sKl), the circulating protein cleaved from membrane-bound Klotho, is reduced significantly with kidney disease and inversely associated with mortality. sKl has not been thoroughly evaluated prospectively after kidney transplantation. Incident kidney transplant recipients (KTRs) were prospectively evaluated pretransplantation, 1, 12 and 52 weeks post-transplantation. Basic biochemistry, sKl and intact FGF23 were measured. Within-subject comparisons were evaluated using repeat-measure anova or Friedman's analysis. Effects of immunosuppression and biochemical parameters on sKl and FGF-23 over time were analysed using mixed-effects modelling. Median serum creatinine (sCr) at 1 week was 116 (92-142) μmol/l, and at 52 weeks, all 29 KTRs had a functioning graft with median sCr of 111 (97-131) μmol/l. Compared with baseline, sKl was increased at 52 weeks following an initial decline at 1 week (P < 0.005 and P < 0.01, respectively), while FGF23 was considerably reduced at 52 weeks (P < 0.001). In a mixed-effects model, an increased sKl was not associated with reduction in immunosuppression or evaluated biochemical parameters. Modest increase in sKl is observed one-year postkidney transplantation with excellent early graft function suggesting factors beyond renal capacity may influence circulating sKl. FGF23 normalization was observed. Longer term evaluation in transplantation, specifically addressing the effects of immunosuppression, is required to understand the pathophysiology of the sKl/FGF23 axis and potential for modification.en_US
dc.subjectFibroblast growth factor-23en_US
dc.subjectKidney transplant recipienten_US
dc.subjectPhosphateen_US
dc.subjectSoluble Klothoen_US
dc.titleMineral adaptations following kidney transplantationen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleTransplant Internationalen_US
dc.identifier.affiliationDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Medicine, The University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Nephrology, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Nephrology, Northern Hospital, Epping, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Endocrinology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Nephrology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australiaen_US
dc.identifier.affiliationVictorian Kidney Transplantation Collaborative, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationEastern Health Clinical School, Monash University, Box Hill, Victoria, Australiaen_US
dc.identifier.affiliationSchool of Medicine, Deakin University, Geelong, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28120476en_US
dc.identifier.doi10.1111/tri.12925en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
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