Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16602
Title: The intensive care medicine agenda on acute kidney injury
Authors: Pickkers, Peter;Ostermann, Marlies;Joannidis, Michael;Zarbock, Alexander;Hoste, Eric;Bellomo, Rinaldo;Prowle, John;Darmon, Michael;Bonventre, Joseph V;Forni, Lui;Bagshaw, Sean M;Schetz, Miet
Issue Date: Sep-2017
EDate: 2017-01-30
Citation: Intensive Care Medicine 2017; 43(9): 1198-1209
Abstract: Acute kidney injury (AKI) is a common complication in the critically ill. Current standard of care mainly relies on identification of patients at risk, haemodynamic optimization, avoidance of nephrotoxicity and the use of renal replacement therapy (RRT) in established AKI. The detection of early biomarkers of renal tissue damage is a recent development that allows amending the late and insensitive diagnosis with current AKI criteria. Increasing evidence suggests that the consequences of an episode of AKI extend long beyond the acute hospitalization. Citrate has been established as the anticoagulant of choice for continuous RRT. Conflicting results have been published on the optimal timing of RRT and on the renoprotective effect of remote ischaemic preconditioning. Recent research has contradicted that acute tubular necrosis is the common pathology in AKI, that septic AKI is due to global kidney hypoperfusion, that aggressive fluid therapy benefits the kidney, that vasopressor therapy harms the kidney and that high doses of RRT improve outcome. Remaining uncertainties include the impact of aetiology and clinical context on pathophysiology, therapy and prognosis, the clinical benefit of biomarker-driven interventions, the optimal mode of RRT to improve short- and long-term patient and kidney outcomes, the contribution of AKI to failure of other organs and the optimal approach for assessing and promoting renal recovery. Based on the established gaps in current knowledge the trials that must have priority in the coming 10 years are proposed together with the definition of appropriate clinical endpoints.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16602
DOI: 10.1007/s00134-017-4687-2
ORCID: 0000-0002-1650-8939
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/28138736
Type: Journal Article
Subjects: Acute kidney injury
Biomarkers
Fluid therapy
Renal replacement therapy
Research agenda
Trial endpoints
Appears in Collections:Journal articles

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