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Title: Self-reported confusion is related to global and regional β-amyloid: data from the Women's healthy ageing project
Authors: McCluskey, Georgia E;Yates, Paul A;Villemagne, Victor L;Rowe, Christopher C;Szoeke, Cassandra EI
Issue Date: Feb-2018
EDate: 2017-01-20
Citation: Brain Imaging and Behavior 2018; 12(1): 78-86
Abstract: Disease-modifying treatments for Alzheimer's disease (AD) may require implementation during early stages of β-amyloid accumulation, well before patients have objective cognitive decline. In this study we aimed to assess the clinical value of subjective cognitive impairment (SCI) by examining the cross-sectional relationship between β-amyloid load and SCI. Cerebral β-amyloid and SCI was assessed in a cohort of 112 cognitively normal subjects. Subjective cognition was evaluated using specific questions on memory and cognition and the MAC-Q. Participants had cerebral β-amyloid load measured with 18F-Florbetaben Positron Emission Tomography (PET). No associations were found between measures of subjective memory impairment and cerebral β-amyloid. However, by self-reported confusion was predictive of a higher global β-amyloid burden (p = 0.002), after controlling for confounders. Regional analysis revealed significant associations of confusion with β-amyloid in the prefrontal region (p = 0.004), posterior cingulate and precuneus cortices (p = 0.004) and the lateral temporal lobes (p = 0.001) after controlling for confounders. An in vivo biomarker for AD pathology was associated with SCI by self-reported confusion on cross-sectional analysis. Whilst there has been a large body of research on SMC, our results indicate more research is needed to explore symptoms of confusion.
DOI: 10.1007/s11682-016-9668-5
ORCID: 0000-0003-3910-2453
PubMed URL:
Type: Journal Article
Subjects: Alzheimer’s disease
PET imaging
Subjective cognitive impairment
Subjective memory
Appears in Collections:Journal articles

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