Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16549
Title: Insights to the schizophrenia continuum: a systematic review of saccadic eye movements in schizotypy and biological relatives of schizophrenia patients
Authors: Myles, Jessica B;Rossell, Susan L;Phillipou, Andrea;Thomas, Elizabeth;Gurvich, Caroline
Issue Date: Jan-2017
EDate: 2016-12-01
Citation: Neuroscience & Biobehavioral Reviews 2017; 72: 278-300
Abstract: One of the cognitive hallmarks of schizophrenia is impaired eye movements, particularly for the antisaccade task. Less saccade research has been conducted in relation to the broader schizophrenia continuum, that is, people with high schizotypy or first-degree relatives of people with schizophrenia. This systematic review sought to identify, collate and appraise prosaccade, antisaccade and memory-guided saccade studies involving behavioural, neuroimaging and genetic data published between 1980 and September 2016 in individuals with high schizotypy and first-degree relatives. A systematic literature search was conducted, using Ovid MEDLINE, PsycINFO, PubMed and SCOPUS databases. Of 913 references screened, 18 schizotypy, 29 family studies and two schizotypy and relatives articles studies were eligible for inclusion. Antisaccade error rate was the most consistent deficit found for high schizotypy. Relatives had intermediate antisaccade error rates between patients and healthy controls. Results from the limited genetic and neuroimaging studies echoed schizophrenia findings. Confounds were also identified. It was concluded that future research is required to refine the saccade endophenotype and to expand genetic and neuroimaging research.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16549
DOI: 10.1016/j.neubiorev.2016.10.034
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/27916709
Type: Journal Article
Subjects: Antisaccades
Continuum model
Endophenotypes
Eye movements
First-degree relatives
Genetics
Memory-guided saccades
Neuroimaging
Prosaccades
Saccades
Schizophrenia
Schizotypy
Appears in Collections:Journal articles

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