Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16516
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dc.contributor.authorChan, MTVen_US
dc.contributor.authorPeyton, Philip Jen_US
dc.contributor.authorMyles, PSen_US
dc.contributor.authorLeslie, Ken_US
dc.contributor.authorBuckley, Nen_US
dc.contributor.authorKasza, Jen_US
dc.contributor.authorPaech, MJen_US
dc.contributor.authorBeattie, WSen_US
dc.contributor.authorSessler, DIen_US
dc.contributor.authorForbes, Aen_US
dc.contributor.authorWallace, Sen_US
dc.contributor.authorChen, Yen_US
dc.contributor.authorTian, Yen_US
dc.contributor.authorWu, WKKen_US
dc.date2016-12en_US
dc.date.accessioned2017-01-16T02:54:18Z-
dc.date.available2017-01-16T02:54:18Z-
dc.date.issued2016-12-
dc.identifier.citationBritish Journal of Anaesthesia 2016; 117(6): 801-811en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16516-
dc.description.abstractBACKGROUND: Previous animal and clinical studies showed that nitrous oxide may produce long-term analgesia. The aim of this study was to evaluate the effect of nitrous oxide in preventing chronic postsurgical pain. We also explored whether methylenetetrahydrofolate reductase gene polymorphisms (1298A>C, 667C>T) would enhance nitrous oxide analgesia. METHODS: We conducted a telephone interview at 12 months after surgery on 2924 (41.1%) patients enrolled in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia-II trial. Pain at the wound site was recorded using the modified brief pain inventory and the neuropathic pain questionnaire. General health status was measured using the EQ-5D questionnaire. Genotyping was performed in a subset of 674 Asian patients in Hong Kong. RESULTS: At 12 months after surgery, 356 (12.2%) patients reported chronic postsurgical pain at the wound site and 112 (3.8%) patients had severe pain and required regular analgesic interventions. Nitrous oxide did not affect the rate of chronic postsurgical pain (11.8% nitrous oxide group; 12.5% no nitrous oxide group), relative risk (95% confidence intervals): 0.94 (0.75-1.17), P=0.57. However, in a planned subgroup analysis, nitrous oxide reduced the risk of chronic postsurgical pain in Asian patients, relative risk (95% confidence intervals): 0.70 (0.50-0.98), P=0.031. Patients who were homozygous for either gene polymorphism and who received nitrous oxide during surgery were less likely to report chronic postsurgical pain. CONCLUSIONS: Nitrous oxide administration had no impact on chronic postsurgical pain, but benefits may still be possible in Asian patients and patients with variants in methylenetetrahydrofolate reductase gene. CLINICAL TRIAL REGISTRATION: NCT00430989.en_US
dc.language.isoenen_US
dc.subjectChronic painen_US
dc.subjectNitrous oxideen_US
dc.subjectPolymorphismen_US
dc.subjectSingle nucleotideen_US
dc.subjectSurgeryen_US
dc.titleChronic postsurgical pain in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trialen_US
dc.typeJournal Articleen_US
dc.identifier.affiliationDepartment of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Chinaen_US
dc.identifier.affiliationDepartment of Anaesthesia, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Anaesthesia and Perioperative Medicine, The Alfred Hospital, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Anaesthesia and Perioperative Medicine, Monash University, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationAnaesthesia, Perioperative and Pain Medicine Unit, University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Pharmacology and Therapeutics, University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Anesthesia, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canadaen_US
dc.identifier.affiliationDepartment of Anaesthesia and Pain Medicine, Royal Perth Hospital, Perth, Western Australia, Australiaen_US
dc.identifier.affiliationSchool of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australiaen_US
dc.identifier.affiliationDepartment of Anesthesia, University of Toronto, Toronto, Ontario, Canadaen_US
dc.identifier.affiliationDepartment of Anaesthesia, Toronto General Hospital, Toronto, Ontario, Canadaen_US
dc.identifier.affiliationDepartment of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USAen_US
dc.identifier.affiliationLi Ka Shing Institute of Health Sciences, Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong Special Administrative Region, Chinaen_US
dc.identifier.affiliationState Key Laboratory of Digestive Disease, Chinese University of Hong Kong, Hong Kong Special Administrative Region, Chinaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/27956679en_US
dc.identifier.doi10.1093/bja/aew338en_US
dc.contributor.corpauthorAustralian and New Zealand College of Anaesthetists Clinical Trials Network for the ENIGMA-II investigatorsen_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
local.name.researcherPeyton, Philip J
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptAnaesthesia-
crisitem.author.deptInstitute for Breathing and Sleep-
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