Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16510
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dc.contributor.authorChoy, Matthew C-
dc.contributor.authorVisvanathan, Kumar-
dc.contributor.authorDe Cruz, Peter-
dc.date.accessioned2017-01-15T23:04:51Z-
dc.date.available2017-01-15T23:04:51Z-
dc.date.issued2017-01-
dc.identifier.citationInflammatory Bowel Diseases 2017; 23(1): 2-13en_US
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/16510-
dc.description.abstractInflammatory bowel diseases (IBDs) are thought to develop as a result of complex interactions between host genetics, the immune system and the environment including the gut microbiome. Although an improved knowledge of the immunopathogenesis of IBDs has led to great advances in therapy such as the highly effective anti-tumor necrosis factor class of medications, a significant proportion of patients with Crohn's disease and ulcerative colitis do not respond to anti-tumor necrosis factor antibodies. Further understanding of the different immune pathways involved in the genesis of chronic intestinal inflammation is required to help find effective treatments for IBDs. In this review, the role of the mucosal innate and adaptive immune system in IBD is summarized, highlighting new areas of discovery which may hold the key to identifying novel predictive or prognostic biomarkers and new avenues of therapeutic discovery.en_US
dc.subjectAdaptive Immunity-
dc.subjectColitis, Ulcerative-
dc.subjectCrohn Disease-
dc.subjectImmunity, Innate-
dc.titleAn overview of the innate and adaptive immune system in inflammatory bowel diseaseen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleInflammatory Bowel Diseasesen_US
dc.identifier.pubmedurihttps://www.ncbi.nlm.nih.gov/pubmed/27779499en_US
dc.identifier.doi10.1097/MIB.0000000000000955en_US
dc.description.affiliatesDepartment of Gastroenterology, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.description.affiliatesDepartment of Gastroenterology, St Vincent's Hospital, Melbourne, Australiaen_US
dc.description.affiliatesDepartment of Medicine, Austin Academic Centre, University of Melbourne, Melbourne, Australiaen_US
dc.description.affiliatesDepartment of Medicine, Eastern Hill Academic Centre, University of Melbourne, Melbourne, Australiaen_US
dc.type.contentTexten_US
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