Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16493
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dc.contributor.authorWeller, Carolina D-
dc.contributor.authorBarker, Anna-
dc.contributor.authorDarby, Ian A-
dc.contributor.authorHaines, Terrence-
dc.contributor.authorUnderwood, Martin-
dc.contributor.authorWard, Stephanie-
dc.contributor.authorAldons, Pat-
dc.contributor.authorDapiran, Elizabeth-
dc.contributor.authorMadan, Jason J-
dc.contributor.authorLoveland, Paula-
dc.contributor.authorSinha, Sankar-
dc.contributor.authorVicaretti, Mauro-
dc.contributor.authorWolfe, Rory-
dc.contributor.authorWoodward, Michael M-
dc.contributor.authorMcNeil, John-
dc.date.accessioned2017-01-11T03:35:29Z-
dc.date.available2017-01-11T03:35:29Z-
dc.date.issued2016-04-11-
dc.identifier.citationTrials 2016; 17: 192en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16493-
dc.description.abstractBackground: Venous leg ulceration is a common and costly problem that is expected to worsen as the population ages. Current treatment is compression therapy; however, up to 50 % of ulcers remain unhealed after 2 years, and ulcer recurrence is common. New treatments are needed to address those wounds that are more challenging to heal. Targeting the inflammatory processes present in venous ulcers is a possible strategy. Limited evidence suggests that a daily dose of aspirin may be an effective adjunct to aid ulcer healing and reduce recurrence. The Aspirin in Venous Leg Ulcer study (ASPiVLU) will investigate whether 300-mg oral doses of aspirin improve time to healing. Methods/design: This randomised, double-blinded, multicentre, placebo-controlled, clinical trial will recruit participants with venous leg ulcers from community settings and hospital outpatient wound clinics across Australia. Two hundred sixty-eight participants with venous leg ulcers will be randomised to receive either aspirin or placebo, in addition to compression therapy, for 24 weeks. The primary outcome is time to healing within 12 weeks. Secondary outcomes are ulcer recurrence, wound pain, quality of life and wellbeing, adherence to study medication, adherence to compression therapy, serum inflammatory markers, hospitalisations, and adverse events at 24 weeks. Discussion: The ASPiVLU trial will investigate the efficacy and safety of aspirin as an adjunct to compression therapy to treat venous leg ulcers. Study completion is anticipated to occur in December 2018. Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12614000293662en_US
dc.subjectAspirinen_US
dc.subjectVenous leg ulcersen_US
dc.subjectCompressionen_US
dc.subjectHealingen_US
dc.titleAspirin in venous leg ulcer study (ASPiVLU): study protocol for a randomised controlled trialen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleTrialsen_US
dc.identifier.affiliationDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationFaculty of Medicine, Nursing and Health Sciences, School of Public Health & Preventive Medicine, The Alfred Centre, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationSchool of Medical Sciences, RMIT University, Bundoora, Victoria, Australiaen_US
dc.identifier.affiliationClinical Trials Unit, University of Warwick, Coventry, UKen_US
dc.identifier.affiliationPrivate Practice Clinic, Prince Charles Hospital, Chermside, Queensland, Australiaen_US
dc.identifier.affiliationChronic Wound Clinic, Caulfield Hospital, Caulfield, Victoria, Australiaen_US
dc.identifier.affiliationSchool of Medicine, University of Tasmania, Hobart, Tasmania, Australiaen_US
dc.identifier.affiliationWestmead Clinical School, Westmead Hospital, Westmead, NSW, Australiaen_US
dc.identifier.affiliationAged Care Services, Heidelberg Repatriation Hospital, Austin Health, Heidelberg West, Victoria, Australiaen_US
dc.type.studyortrialRandomized Controlled Clinical Trial/Controlled Clinical Trialen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/27068695en_US
dc.identifier.doi10.1186/s13063-016-1314-4en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
local.name.researcherWoodward, Michael M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptAged Care-
crisitem.author.deptGeriatric Medicine-
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