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|Title:||Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia|
|Authors:||van Hal, Sebastiaan J;Espedido, Björn A;Coombs, Geoffrey W;Howden, Benjamin P;Korman, Tony M;Nimmo, Graeme R;Gosbell, Iain B;Jensen, Slade O|
|Citation:||Journal of Antimicrobial Chemotherapy 2016; online first: 28 December|
|Abstract:||Objectives: To investigate the genetic context associated with the emergence of vanA VRE in Australia. Methods: The whole genomes of 18 randomly selected vanA-positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced and analysed. Results: In silico typing and transposon/plasmid assembly revealed that the sequenced isolates represented (in most cases) different hospital-adapted STs and were associated with a variety of different Tn1546 variants and plasmid backbone structures. Conclusions: The recent emergence of vanA VRE in Australia was polyclonal and not associated with the dissemination of a single ‘dominant’ ST or vanA-encoding plasmid. Interestingly, the factors contributing to this epidemiological change are not known and future studies may need to consider investigation of potential community sources.|
|Appears in Collections:||Journal articles|
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