Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16441
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dc.contributor.authorRayner, Genevieve-
dc.contributor.authorJackson, Graeme-
dc.contributor.authorWilson, Sarah J-
dc.date2015-11-10-
dc.date.accessioned2016-11-23T01:05:44Z-
dc.date.available2016-11-23T01:05:44Z-
dc.date.issued2016-02-
dc.identifier.citationNeuroscience & Biobehavioral Reviews 2016; 61: 53-56en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16441-
dc.description.abstractThis systematic review sources the latest neuroimaging evidence for the role of cognition-related brain networks in depression, and relates their abnormal functioning to symptoms of the disorder. Using theoretically informed and rigorous inclusion criteria, we integrate findings from 59 functional neuroimaging studies of adults with unipolar depression using a narrative approach. Results demonstrate that two distinct neurocognitive networks, the autobiographic memory network (AMN) and the cognitive control network (CCN), are central to the symptomatology of depression. Specifically, hyperactivity of the introspective AMN is linked to pathological brooding, self-blame, rumination. Anticorrelated under-engagement of the CCN is associated with indecisiveness, negative automatic thoughts, poor concentration, distorted cognitive processing. Downstream effects of this imbalance include reduced regulation of networks linked to the vegetative and affective symptoms of depression. The configurations of these networks can change between individuals and over time, plausibly accounting for both the variable presentation of depressive disorders and their fluctuating course. Framing depression as a disorder of neurocognitive networks directly links neurobiology to psychiatric practice, aiding researchers and clinicians alike.en_US
dc.subjectAffecten_US
dc.subjectCognitionen_US
dc.subjectDepressive Symptomsen_US
dc.subjectFunctional Neuroimagingen_US
dc.subjectNeural networks (anatomic)en_US
dc.subjectNeuropsychiatryen_US
dc.subjectNeuropsychologyen_US
dc.titleCognition-related brain networks underpin the symptoms of unipolar depression: evidence from a systematic reviewen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleNeuroscience & Biobehavioral Reviewsen_US
dc.identifier.affiliationMelbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health (Austin Campus), Brain Research Institute, Melbourne Brain Centre, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationComprehensive Epilepsy Programme, Austin Health, Melbourne Brain Centre, Heidelberg, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/26562681en_US
dc.identifier.doi10.1016/j.neubiorev.2015.09.022en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
local.name.researcherRayner, Genevieve
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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