Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16441
Title: Cognition-related brain networks underpin the symptoms of unipolar depression: evidence from a systematic review
Authors: Rayner, Genevieve;Jackson, Graeme;Wilson, Sarah J
Issue Date: Feb-2016
EDate: 2015-11-10
Citation: Neuroscience & Biobehavioral Reviews 2016; 61: 53-56
Abstract: This systematic review sources the latest neuroimaging evidence for the role of cognition-related brain networks in depression, and relates their abnormal functioning to symptoms of the disorder. Using theoretically informed and rigorous inclusion criteria, we integrate findings from 59 functional neuroimaging studies of adults with unipolar depression using a narrative approach. Results demonstrate that two distinct neurocognitive networks, the autobiographic memory network (AMN) and the cognitive control network (CCN), are central to the symptomatology of depression. Specifically, hyperactivity of the introspective AMN is linked to pathological brooding, self-blame, rumination. Anticorrelated under-engagement of the CCN is associated with indecisiveness, negative automatic thoughts, poor concentration, distorted cognitive processing. Downstream effects of this imbalance include reduced regulation of networks linked to the vegetative and affective symptoms of depression. The configurations of these networks can change between individuals and over time, plausibly accounting for both the variable presentation of depressive disorders and their fluctuating course. Framing depression as a disorder of neurocognitive networks directly links neurobiology to psychiatric practice, aiding researchers and clinicians alike.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16441
DOI: 10.1016/j.neubiorev.2015.09.022
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/26562681
Type: Journal Article
Subjects: Affect
Cognition
Depressive Symptoms
Functional Neuroimaging
Neural networks (anatomic)
Neuropsychiatry
Neuropsychology
Appears in Collections:Journal articles

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