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Title: Resolution of norfloxacin-induced acute liver failure after N-acetylcysteine therapy: further support for the use of NAC in drug-induced ALF?
Authors: Elliott, Timothy Ross;Symes, Tiffany;Kannourakis, George;Angus, Peter W
Issue Date: 6-Jan-2016
EDate: 2016-01-06
Citation: BMJ Case Reports 2016; online first: 6 January
Abstract: Liver injury due to idiosyncratic drug reactions can be difficult to diagnose and may lead to acute liver failure (ALF), which has a high mortality rate. N-acetylcysteine (NAC) is effective treatment for paracetamol toxicity, but its role in non-paracetamol drug-induced ALF is controversial. We report on the use of a validated bedside tool to establish causality for drug-induced liver injury (DILI) and describe the first case of resolution of norfloxacin-induced ALF after NAC therapy. NAC is easy to administer and generally has a good safety profile. We discuss the evidence to support the use of NAC in ALF secondary to DILI and possibilities for further clinical research in this field.
DOI: 10.1136/bcr-2015-213189
PubMed URL:
Type: Journal Article
Subjects: Acetylcysteine
Anti-Bacterial Agents
Drug-Induced Liver Injury
Appears in Collections:Journal articles

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