Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16423
Title: β-Amyloid, APOE and BDNF genotype, and depressive and anxiety symptoms in cognitively normal older women and men
Authors: Holmes, Sophie E;Esterlis, Irina;Mazure, Carolyn M;Lim, Yen Ying;Ames, David;Rainey-Smith, Stephanie R;Martins, Ralph N;Salvado, Olivier;Dore, Vincent;Villemagne, Victor L;Rowe, Christopher C;Laws, Simon M;Masters, Colin L;Maruff, Paul;Pietrzak, Robert H
Institutional Author: AIBL Research Group
Issue Date: Dec-2016
EDate: 2016-08-17
Citation: American Journal of Geriatric Psychiatry 2016; 24(12): 1191-1195
Abstract: OBJECTIVE: To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men. METHODS: Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle study. Analyses of covariance evaluated associations between Aβ, APOE and BDNF genotype, and cortisol in relation to severity of depressive and anxiety symptoms. RESULTS: Among Aβ+ older adults, APOE ε4 carriage was associated with greater severity of anxiety symptoms (d = 0.55); and in the full sample, APOE ε4 carriage was linked to greater severity of depressive (d = 0.26) and anxiety (d = 0.21) symptoms. Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d = 0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d = 0.29). CONCLUSION: Sex moderated the relationship between Aβ, APOE genotype, and BDNF genotype in predicting severity of anxiety and depressive symptoms in cognitively normal older adults.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16423
DOI: 10.1016/j.jagp.2016.08.007
ORCID: 0000-0003-3910-2453
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/27742526
Type: Journal Article
Subjects: APOE
BDNF
Amyloid
Anxiety
Depression
Elderly
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.