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|Title:||Recurrent glioblastoma: current patterns of care in an Australian population|
|Authors:||Parakh, Sagun;Thursfield, Vicky;Cher, Lawrence M;Dally, Michael;Drummond, Katharine J;Murphy, Michael;Rosenthal, Mark A;Gan, Hui K|
|Citation:||Journal of Clinical Neuroscience 2016; 24: 78-82|
|Abstract:||This retrospective population-based survey examined current patterns of care for patients with recurrent glioblastoma (rGBM) who had previously undergone surgery and post-operative therapy at original diagnosis. The patients were identified from the Victorian Cancer Registry (VCR) from 2006 to 2008. Patient demographics, tumour characteristics and oncological management were extracted using a standardised survey by the treating clinicians/VCR staff and results analysed by the VCR. Kaplan–Meier estimates of overall survival (OS) at diagnosis and progression were calculated. A total of 95 patients (48%) received treatment for first recurrence; craniotomy and post-operative treatment (38), craniotomy only (34) and non-surgical treatment (23). Patients receiving treatment at first progression had a higher median OS than those who did not (7 versus 3 months, p < 0.0001). All patients progressed after treatment for first progression with 43 patients (45%) receiving treatment at second progression. To our knowledge this is the first population-based pattern of care survey of treatment for rGBM in an era where post-operative “Stupp” chemo-radiation is standard. First and second line therapy for rGBM is common and associated with significant benefit. Treatment generally includes re-resection and/or systemic therapy.|
|Appears in Collections:||Journal articles|
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