Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16253
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dc.contributor.authorCerin, Ester-
dc.contributor.authorRainey-Smith, Stephanie R-
dc.contributor.authorAmes, David-
dc.contributor.authorLautenschlager, Nicola T-
dc.contributor.authorMacaulay, S Lance-
dc.contributor.authorFowler, Christopher J-
dc.contributor.authorRobertson, Joanne S-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorMaruff, Paul-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorEllis, Kathryn A-
dc.date2016-08-19-
dc.date.accessioned2016-09-13T07:17:16Z-
dc.date.available2016-09-13T07:17:16Z-
dc.date.issued2017-04-
dc.identifier.citationAlzheimer's & Dementia 2017; 13(4): 388-398en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16253-
dc.description.abstractINTRODUCTION: "Walkable" neighborhoods offer older adults opportunities for activities that may benefit cognition-related biological mechanisms. These have not previously been examined in this context. METHODS: We objectively assessed neighborhood walkability for participants (n = 146) from the Australian Imaging, Biomarkers and Lifestyle study with apolipoprotein E (APOE) genotype and two 18-month-apart brain volumetric and/or amyloid β burden assessments. Linear mixed models estimated associations of neighborhood walkability with levels and changes in brain imaging outcomes, the moderating effect of APOE ε4 status, and the extent to which associations were explained by physical activity. RESULTS: Cross-sectionally, neighborhood walkability was predictive of better neuroimaging outcomes except for left hippocampal volume. These associations were to a small extent explained by physical activity. APOE ε4 carriers showed slower worsening of outcomes if living in walkable neighborhoods. DISCUSSION: These findings indicate associations between neighborhood walkability and brain imaging measures (especially in APOE ε4 carriers) minimally attributable to physical activity.en_US
dc.subjectAmyloid beta depositionsen_US
dc.subjectApolipoprotein E genotypeen_US
dc.subjectBrain volumetric measuresen_US
dc.subjectCommunity dwellersen_US
dc.subjectEnriched environmenten_US
dc.subjectHippocampusen_US
dc.subjectPlace of residenceen_US
dc.subjectWalkabilityen_US
dc.titleAssociations of neighborhood environment with brain imaging outcomes in the Australian Imaging, Biomarkers and Lifestyle cohorten_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleAlzheimer's & Dementiaen_US
dc.identifier.affiliationAustin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationInstitute for Health and Ageing, Australian Catholic University, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationSchool of Public Health, The University of Hong Kong, Hong Kong, Chinaen_US
dc.identifier.affiliationSchool of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australiaen_US
dc.identifier.affiliationSir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australiaen_US
dc.identifier.affiliationCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Perth, Western Australia, Australiaen_US
dc.identifier.affiliationAcademic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationNational Ageing Research Institute, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationCSIRO Food and Nutrition, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationCogstate Ltd., Melbourne, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/27546307en_US
dc.identifier.doi10.1016/j.jalz.2016.06.2364en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0003-3910-2453en_US
dc.type.austinJournal Articleen_US
local.name.researcherMasters, Colin L
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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