Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16241
Title: Fully automated synthesis of [(18) F]fluoro-dihydrotestosterone ([(18) F]FDHT) using the FlexLab module
Authors: Ackermann, Uwe;Lewis, Jason S;Young, Kenneth;Morris, Michael J;Weickhardt, Andrew;Davis, Ian D;Scott, Andrew M
Issue Date: Aug-2016
EDate: 2016-07-04
Citation: Journal of Labelled Compounds and Radiopharmaceuticals 2016; 59(10): 424-428
Abstract: Imaging of androgen receptor expression in prostate cancer using F-18 FDHT is becoming increasingly popular. With the radiolabelling precursor now commercially available, developing a fully automated synthesis of [(18) F] FDHT is important. We have fully automated the synthesis of F-18 FDHT using the iPhase FlexLab module using only commercially available components. Total synthesis time was 90 min, radiochemical yields were 25-33% (n = 11). Radiochemical purity of the final formulation was > 99% and specific activity was > 18.5 GBq/µmol for all batches. This method can be up-scaled as desired, thus making it possible to study multiple patients in a day. Furthermore, our procedure uses 4 mg of precursor only and is therefore cost-effective. The synthesis has now been validated at Austin Health and is currently used for [(18) F]FDHT studies in patients. We believe that this method can easily adapted by other modules to further widen the availability of [(18) F]FDHT.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16241
DOI: 10.1002/jlcr.3417
ORCID: 0000-0002-9066-8244
0000-0002-6656-295X
PubMed URL: http://www.ncbi.nlm.nih.gov/pubmed/27378195
Type: Journal Article
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.