Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16223
Title: Hippocampal malrotation is an anatomic variant and has no clinical significance in MRI-negative temporal lobe epilepsy
Authors: Tsai, Meng-Han;Vaughan, David N;Perchyonok, Yuliya;Fitt, Gregory J;Scheffer, Ingrid E;Berkovic, Samuel F;Jackson, Graeme D
Issue Date: 26-Aug-2016
EDate: 2016-08-26
Citation: Epilepsia 2016; online first: 26 August
Abstract: OBJECTIVE: There is considerable difficulty in diagnosing hippocampal malrotation (HIMAL), with different criteria of variable reliability. Here we assess qualitative and quantitative criteria in HIMAL diagnosis and explore the role of HIMAL in magnetic resonance imaging (MRI)-negative temporal lobe epilepsy (TLE). METHODS: We studied the MRI of 155 adult patients with MRI-negative TLE and 103 healthy volunteers, and we asked (1) what are the qualitative and quantitative features that allow a reliable diagnosis of HIMAL, (2) how common is HIMAL in a normal control population, and (3) is HIMAL congruent with the epileptogenic side in MRI-negative TLE. RESULTS: We found that the features that are most correlated with the expert diagnosis of HIMAL are hippocampal shape change with hippocampal diameter ratio > 0.8, lack of normal lateral convex margin, and a deep dominant inferior temporal sulcus (DITS) with DITS height ratio > 0.6. In a blinded analysis, a consensus diagnosis of unilateral or bilateral HIMAL was made in 25 of 103 controls (24.3% of people, 14.6% of hippocampi-14 left, six right, 10 bilateral) that did not differ from 155 lesion-negative TLE patients where 25 had HIMAL (16.1% of patients, 11.6% of hippocampi-12 left, two right, 11 bilateral). Of the 12 with left HIMAL only, 9 had seizures arising from the left temporal lobe, whereas 3 had right-sided seizures. Of the two with right HIMAL only, both had seizures arising from the left temporal lobe. SIGNIFICANCE: HIMAL is an anatomic variant commonly found in controls. HIMAL is also an incidental nonpathologic finding in adult MRI-negative TLE and should not influence surgical decision making.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16223
DOI: 10.1111/epi.13505
ORCID: 0000-0002-2311-2174
0000-0003-4580-841X
PubMed URL: http://www.ncbi.nlm.nih.gov/pubmed/27562507
Type: Journal Article
Subjects: Hippocampal sclerosis
Incomplete hippocampal infolding
Lesion-negative epilepsy
Neuroimaging
Appears in Collections:Journal articles

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