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|Title:||A randomised controlled trial of peri-operative lidocaine infusions for open radical prostatectomy|
|Authors:||Weinberg, Laurence;Rachbuch, C;Ting, S;Howard, W;Yeomans, M;Gordon, I;McNicol, L;James, K;Story, David A;Christophi, Christopher|
|Citation:||Anaesthesia 2016; 71(4): 405-410|
|Abstract:||We allocated 76 men scheduled for radical retropubic prostatectomy to peri-operative lidocaine 2% or saline 0.9%: a pre-operative 0.075 ml.kg(-1) intravenous bolus; an intra-operative intravenous infusion at 0.075 ml.kg(-1) .h(-1) ; and 24 hours' postoperative subcutaneous infusion at 0.075 ml.kg(-1) .h(-1) . Lidocaine reduced the postoperative hospital stay by a mean (95% CI) of 1.3 (0.3-2.4) days, p = 0.017, from a mean (SD) of 4.6 (3.2) days with saline. Lidocaine reduced pain at rest during the first 24 postoperative hours by a mean (95% CI) of 1.8 (0.7-2.9) mm.h(-1) , p = 0.001. Lidocaine reduced 24-h morphine consumption by a mean (95% CI) of 13.9 (2.2-25.7) mg, p = 0.021, from a mean (SD) of 52.3 (26.9) mg with saline. There were no differences in other outcomes.|
|Appears in Collections:||Journal articles|
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