Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16110
Title: Mortality in mild cognitive impairment: A longitudinal study in memory clinics
Authors: Connors, Michael H;Ames, David;Boundy, Karyn;Clarnette, Roger;Kurrle, Sue;Mander, Alastair G;Ward, John;Woodward, Michael M;Brodaty, Henry
Issue Date: 27-Jul-2016
EDate: 2016-07-27
Citation: Journal of Alzheimer's Disease 2016; 54(1): 149-155
Abstract: Background: Patients with mild cognitive impairment (MCI) are at greater risk of mortality than the general population. Comparatively little research has examined predictors of mortality in MCI and no research has examined whether time-varying variables, such as change in cognition and function, predict survival. Objective: To identify predictors of mortality in patients with MCI. Methods: 185 patients with MCI were recruited from nine memory clinics around Australia. Patients completed measures of cognition, function, and neuropsychiatric symptoms over three years. Mortality data were obtained from state registries eight years after baseline. Results: 55 (30%) patients died within this period. Older age, lower cognitive and functional ability at baseline, and greater decline in functional ability over six months predicted mortality. Conclusion: Easily measurable clinical data predict mortality in patients with MCI. Longitudinal assessment over time can provide additional information about patients’ risk.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16110
DOI: 10.3233/JAD-160148
PubMed URL: http://www.ncbi.nlm.nih.gov/pubmed/27472874
Type: Journal Article
Subjects: Lifespan
Longitudinal Studies
Mild cognitive impairment
Mortality
Risk factors
Survival
Appears in Collections:Journal articles

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