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Title: Upregulation of circulating components of the alternative renin-angiotensin system in inflammatory bowel disease: A pilot study
Authors: Garg, Mayur;Burrell, Louise M;Velkoska, Elena;Griggs, Karen;Angus, Peter W;Gibson, Peter R;Lubel, John S
Affiliation: Victorian Liver Transplant Unit, Austin Health, Heidelberg, Victoria, Australia
Issue Date: Sep-2015
EDate: 2014-02-06
Citation: Journal of the Renin-Angiotensin-Aldosterone System 2015; 16(3):559-569
Abstract: INTRODUCTION: The relationship between intestinal inflammation and circulating components of the renin-angiotensin system (RAS) is poorly understood. MATERIALS AND METHODS: Demographic and clinical data were obtained from healthy controls and patients with inflammatory bowel disease (IBD). Plasma concentrations of the classical RAS components (angiotensin-converting enzyme (ACE) and angiotensin II (Ang II)) and alternative RAS components (ACE2 and angiotensin (1-7) (Ang (1-7))) were analysed by radioimmuno- and enzymatic assays. Systemic inflammation was assessed using serum C-reactive protein (CRP), white cell count, platelet count and albumin, and intestinal inflammation by faecal calprotectin. RESULTS: Nineteen healthy controls (11 female; mean age 38 years, range 23-68), 19 patients with Crohn's disease (11 female; aged 45 years, range 23-76) and 15 patients with ulcerative colitis (6 female; aged 42 years, 26-64) were studied. Circulating classical RAS component levels were similar across the three groups, whereas ACE2 activity and Ang (1-7) concentrations were higher in patients with IBD compared to controls (ACE2: 21.5 vs 13.3 pmol/ml/min, p<0.05; Ang (1-7): 22.8 vs 14.1 pg/ml, p<0.001). Ang (1-7) correlated weakly with platelet and white cell counts, but not calprotectin or CRP, in patients with IBD. CONCLUSIONS: Circulating components of the alternative RAS are increased in patients with IBD.
DOI: 10.1177/1470320314521086
ORCID: 0000-0003-1863-7539
PubMed URL:
Type: Journal Article
Subjects: Crohn’s disease
Renin-angiotensin system
Angiotensin (1–7)
Angiotensin II
Angiotensin-converting enzyme
Angiotensin-converting enzyme 2
Inflammatory bowel disease
Ulcerative colitis
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