Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16050
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dc.contributor.authorLeung, Christopher-
dc.contributor.authorRivera, L-
dc.contributor.authorFurness, John B-
dc.contributor.authorAngus, Peter W-
dc.date2016-06-08-
dc.date.accessioned2016-06-21T04:19:39Z-
dc.date.available2016-06-21T04:19:39Z-
dc.date.issued2016-07-
dc.identifier.citationNature Reviews Gastroenterology & Hepatology 2016; 13(7): 412-425en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16050-
dc.description.abstractNAFLD is now the most common cause of liver disease in Western countries. This Review explores the links between NAFLD, the metabolic syndrome, dysbiosis, poor diet and gut health. Animal studies in which the gut microbiota are manipulated, and observational studies in patients with NAFLD, have provided considerable evidence that dysbiosis contributes to the pathogenesis of NAFLD. Dysbiosis increases gut permeability to bacterial products and increases hepatic exposure to injurious substances that increase hepatic inflammation and fibrosis. Dysbiosis, combined with poor diet, also changes luminal metabolism of food substrates, such as increased production of certain short-chain fatty acids and alcohol, and depletion of choline. Changes to the microbiome can also cause dysmotility, gut inflammation and other immunological changes in the gut that might contribute to liver injury. Evidence also suggests that certain food components and lifestyle factors, which are known to influence the severity of NAFLD, do so at least in part by changing the gut microbiota. Improved methods of analysis of the gut microbiome, and greater understanding of interactions between dysbiosis, diet, environmental factors and their effects on the gut-liver axis should improve the treatment of this common liver disease and its associated disorders.en_US
dc.titleThe role of the gut microbiota in NAFLDen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleNature Reviews Gastroenterology & Hepatologyen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.affiliationMetabolic Research Unit, School of Medicine, Deakin University, Geelong, VIC 3216, Australiaen_US
dc.identifier.affiliationDepartment of Anatomy and Neuroscience, University of Melbourne, Grattan Street, Parkville, VIC 3010, Australiaen_US
dc.identifier.affiliationGastroenterology and Hepatologyen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/27273168en_US
dc.identifier.doi10.1038/nrgastro.2016.85en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
local.name.researcherAngus, Peter W
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptUniversity of Melbourne Clinical School-
crisitem.author.deptClinical Education-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
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