Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16034
Title: Correction for diffusion MRI fibre tracking biases: The consequences for structural connectomic metrics.
Authors: Yeh, Chun-Hung;Smith, Robert E;Liang, Xiaoyun;Calamante, Fernando;Connelly, Alan
Affiliation: Department of Medicine, Northern Health, University of Melbourne, Melbourne, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 15-Nov-2016
EDate: 2016-05-19
Citation: Neuroimage 2016; 142: 150-162
Abstract: Diffusion MRI streamlines tractography has become a major technique for inferring structural networks through reconstruction of brain connectome. However, quantification of structural connectivity based on the number of streamlines interconnecting brain grey matter regions is known to be problematic in a number of aspects, such as the ill-posed nature of streamlines terminations and the non-quantitative nature of streamline counts. This study investigates the effects of state-of-the-art connectome construction methods on the subsequent analyses of structural brain networks using graph theoretical approaches. Our results demonstrate that the characteristics of structural connectivity, including connectome variability, global network metrics, small-world attributes and network hubs, alter significantly following the improvement in biological accuracy of streamlines tractograms provided by anatomically-constrained tractography (ACT) and spherical-deconvolution informed filtering of tractograms (SIFT). Importantly, the commonly-used correction for connection density based on scaling the contribution of each streamline to the connectome by its inverse length is shown to provide incomplete correction, highlighting the necessity for the use of advanced tractogram reconstruction techniques in structural connectomics research.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16034
DOI: 10.1016/j.neuroimage.2016.05.047
PubMed URL: http://www.ncbi.nlm.nih.gov/pubmed/27211472
Type: Journal Article
Subjects: Diffusion MRI
Fibre-tracking
Tractography
Structural connectome
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.