Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13727
Title: Anti-Tumour necrosis factor α therapies and inflammatory bowel disease pregnancy outcomes: A meta-analysis
Authors: Shihab, Z;Yeomans, ND;De Cruz, P
Issue Date: 2016
EDate: 2016-01-11
Citation: 2016 Jan 11. pii: jjv234
Abstract: BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) commonly affects women during their reproductive years, leading to concerns regarding pregnancy outcomes and therapeutic safety. The aim of this study was to assess the risks associated with anti-tumour necrosis factor α (anti-TNFα) therapy for pregnancy outcomes, including rates of congenital abnormality, based on published studies. METHODS: Published studies were screened from on-line databases and international meeting abstracts. A meta-analysis was performed for adverse pregnancy outcomes (APOs), congenital abnormalities (CAs), preterm birth (PTB) and low birth weight (LBW). The prevalence of CAs was compared with whole-population pooled registry data. RESULTS: In women exposed to anti-TNFα the pooled odds ratio for APOs was 1.14 (95% confidence interval [CI] 0.73-1.78; p = 0.55) compared with disease-matched controls. The pooled odds ratios for CAs, PTB and LBW were 0.89 (0.37-2.13; p = 0.79), 1.21 (0.74-2.00; p = 0.45) and 1.36 (0.77-2.38; p = 0.29) respectively. The rate of CAs in TNFα-exposed women was not statistically different from that in population-wide registries (difference 0.4%, 95% CI -2.0 to +2.7). CONCLUSIONS: Anti-TNFα therapy does not increase the risk of APOs, CAs, PTB or LBW compared with disease-matched controls. Furthermore, the risk of CAs is not increased when published prevalence data are compared with data for the general population. These findings may offer some reassurance for women and physicians regarding the safety profile of anti-TNFα during pregnancy in IBD.
URI: http://ahro.austin.org.au/austinjspui/handle/1/13727
PubMed URL: http://www.ncbi.nlm.nih.gov/pubmed/26755733
Type: Journal Article
Subjects: Inflammatory Bowel Diseases
Necrosis
Risk Assessment
Pregnancy Outcome
Type of Clinical Study or Trial: Meta-Analysis
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.