Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13713
Title: Patterns and mechanisms of artificial kidney failure during continuous renal replacement therapy
Austin Authors: Zhang, L;Tanaka, A;Zhu, G;Baldwin, Ian C ;Eastwood, Glenn;Bellomo, Rinaldo 
Affiliation: Department of Intensive Care Unit, Austin Hospital, Heidelberg, Australia
Issue Date: 2016
Date: 2016
Publication information: Blood Purification 2016, vol. 41(4) p. 254-263
Abstract: Background: We aimed to describe the previously unstudied relationship between circuit pressures and circuit clotting, here labeled as ‘artificial kidney failure' (AKF), in patients receiving continuous renal replacement therapy (CRRT). Methods: We performed an observational study of CRRT-treated critically ill patients to continuously record the multiple CRRT circuit pressures. Results: Three patterns of access outflow dysfunction (AOD) were also noted: severe, moderate and mild. Compared with circuits without AOD, circuits experiencing at least one AOD episode had shorter lifespans (14.2 ± 12.7 vs. 21.3 ± 16.5 h, p = 0.057). This effect was more obvious with moderate or severe AOD (8.7 ± 4.6 vs. 20.6 ± 15.7 h, p = 0.007). If any AOD events occurred within the first 4 h, the sensitivity and specificity in predicting early-immediate AKF were 53.4 and 94.4%, respectively. Conclusions: Early and intermediate AKF during CRRT is most likely dependent on AOD, which is a frequent event with variable severity.
URI: https://ahro.austin.org.au/austinjspui/handle/1/13713
DOI: 10.1159/000441968
Journal: Blood Purification
Type: Journal Article
Subjects: Renal replacement therapy
Observational study
Kidneys, artificial
Appears in Collections:Journal articles

Show full item record

Page view(s)

26
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.