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Title: Hippocampal and amygdala volume early after stroke lower than controls
Authors: Cumming, T;Warden, E;Li, Q;Brodtmann, A
Issue Date: Oct-2015
Abstract: (Full abstract with images is separate file) Background – Structural brain volume is an important marker of neurodegeneration. Quantifying regional brain volume early after stroke allows us to establish a baseline for longitudinal change measurement. Methods – The Cognition And Neocortical Volume After Stroke (CANVAS) study is an ongoing longitudinal investigation. Ischaemic stroke patients without dementia are recruited and assessed within 6 weeks of stroke, and are compared to healthy age-matched controls. All participants undergo high-resolution 3T MPRAGE MRI to evaluate regional brain volume. Cognitive tasks include the Montreal Cognitive Assessment (MoCA) and the Hopkins Verbal Learning Test-Revised (HVLT-R) for memory. Results – We recruited 85 stroke patients (61 male, age 67.6±12.8 years, education 12.7±3.9 years; days post-stroke 25.9±10.1) and 31 controls (17 male, age 68.8±7.5 years, education 14.9±5.0 years). Adjusting for age and intracranial volume, regional analysis indicated smaller hippocampi (p<0.001; see Figure 1), amygdalae (p=0.009) and cortical thickness (p=0.020) in stroke patients than controls, but no difference in the thalami or caudate nuclei. In stroke patients, smaller hippocampal volume was independently associated with poorer immediate (p=0.001) and delayed (p=0.017) recall on HVLT-R. Smaller amygdala volume was independently associated with lower MoCA score (p=0.002).
Description: Test for abstract with image.
Conference Name: Research Week 2015
Conference Location: Heidelberg, Victoria.
Type: Conference Paper
Appears in Collections:Research Week 2015

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