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Title: Vascular risk factors and Alzheimer's disease pathology in cognitively-normal participants: results from the AIBL Study
Authors: Yates, PA;Villemagne, VL;Ellis, K;Ames, DA;Desmond, P;Masters, C;Rowe, CC
Issue Date: Oct-2015
Abstract: Vascular risk factors (VRF) may be associated with Alzheimer’s disease (AD), and that these associations may be influenced by presence of the APOEε4 allele. We assessed the relationship between VRF and A in vivo using 11C-PiB PET, and for interactions with APOEε4. ¶ Methods Cross-sectional analysis of 178 cognitively-normal participants aged >60 years, with clinical and cognitive assessment, blood biomarkers and 11C-PiB PET. A-burden (PiB SUVR) was calculated for the neocortex, normalized to cerebellum. VRF (Hypertension, Diabetes/Insulin Resistance, Hypercholesterolaemia, Obesity and Smoking) were identified according to published guidelines. The relationship between VRF burden (overall) and individual VRFs with in vivo amyloid was investigated using a series of general linear regression analyses, with PiB SUVR as the dependent variable, and independent variables age, APOEε4 status and VRF, as well as the interaction term, VRF x APOEε4. ¶ Results Age, APOE ε4 carrier status, and VRF burden were independently associated with presence of A. The interaction term VRF x APOEε4 was also associated with A, such that the APOEε4+ with more VRF demonstrated greater PiB-retention. Hypertension and being overweight/obese each interacted with APOE ε4 status to increase risk for A. Hyperglycaemia and insulin resistance were associated with increased A, in both APOEε4 carriers and non-carriers. There was weak evidence (p = 0.1) for an association between cigarette smoking burden and A in APOEε4 carriers. No significant association nor APOEε4 interactions were noted for hypercholesterolaemia or cholesterol treatment. ¶ Conclusion Greater burden of VRF was associated with A in vivo. VRF may increase risk for A, particularly in individuals at higher genetic risk. These are cross-sectional observations only and causality cannot be assumed. Longitudinal follow-up and reproduction of these findings in larger, diverse cohorts is required.
Conference Name: Research Week 2015
Conference Location: Heidelberg, Victoria.
Type: Conference Paper
Appears in Collections:Research Week 2015

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