Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13620
Title: Amylin: physiological roles in the kidney and a hypothesis for its role in hypertension.
Authors: Wookey, Peter J;Cooper, Mark E
Affiliation: Department of Medicine, University of Melbourne, Austin & Repatriation Medical Centre, West Heidelberg, Victoria, Australia. wookey@austin.unimelb.edu.au
Issue Date: 1-Sep-1998
Citation: Clinical and Experimental Pharmacology & Physiology; 25(9): 653-60
Abstract: 1. There are high-affinity binding sites for amylin in the renal cortex associated with proximal tubules. These appear to represent seven transmembrane (heptatopic) receptors that are known to form ternary complexes with G-proteins and activate second messenger systems. 2. Amylin stimulates sodium/water reabsorption from the basolateral side of the proximal tubules and plays a role in sodium homeostasis. 3. The transient expression of amylin-like mRNA has been detected perinatally, using in situ hybridization, in the subnephrogenic zone of the metanephros and is associated with proximal tubules of the developing nephron. There it is thought to play a role as a growth factor for brush border epithelial cells in the developing kidney and in renal regrowth in the adult kidney. 4. In two models of hypertension, the spontaneously hypertensive rat (SHR) and one created surgically by subtotal nephrectomy, renal amylin receptors are activated. In the SHR, activation precedes the rise in blood pressure and suggests that activation of the amylin system may be an important event in the development of hypertension.
Internal ID Number: 9750952
URI: http://ahro.austin.org.au/austinjspui/handle/1/13620
URL: http://www.ncbi.nlm.nih.gov/pubmed/9750952
Type: Journal Article
Subjects: Amyloid.biosynthesis.physiology
Animals
Humans
Hypertension, Renal.metabolism.physiopathology
Islet Amyloid Polypeptide
Kidney.metabolism.physiology
Rats
Rats, Inbred SHR
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.