Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13616
Title: Long-term effects of nonpeptide vasopressin V2 antagonist OPC-31260 in heart failure in the rat.
Authors: Burrell, Louise M;Phillips, P A;Risvanis, John;Chan, Robert K;Aldred, K L;Johnston, Colin I
Affiliation: Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg 3084, Victoria, Australia.
Issue Date: 1-Jul-1998
Citation: The American Journal of Physiology; 275(1 Pt 2): H176-82
Abstract: The hormone arginine vasopressin (AVP) contributes to water retention and vasoconstriction in congestive heart failure (CHF) through effects at the V2 and V1a receptors, respectively. The effect of long-term V2 receptor (V2R) blockade using OPC-31260 was assessed in a rat model of postinfarction-induced CHF. Rats underwent coronary artery ligation or sham operation and were treated for 6 mo with oral OPC-31260 (10 mg . kg-1 . day-1) or vehicle. CHF was characterized by left ventricular remodeling and impaired systolic function, increased cardiac and lung weight, and elevated plasma atrial natriuretic peptide; plasma AVP and plasma renin activity were not increased. Chronic V2R blockade increased urine volume (P < 0.01) and decreased urine osmolality (P < 0.01) but had no natriuretic effects. V2R blockade did not activate the renin-angiotensin system but increased plasma AVP in CHF (P < 0.01). V2R blockade did not influence cardiac remodeling, cardiac function, or survival. These results suggest that AVP plays a major role in water retention through the renal V2R in a rat model of CHF. V2R blockade using OPC-31260 may represent an alternative to standard diuretic therapy in the management of water retention that characterizes heart failure.
Internal ID Number: 9688911
URI: http://ahro.austin.org.au/austinjspui/handle/1/13616
URL: http://www.ncbi.nlm.nih.gov/pubmed/9688911
Type: Journal Article
Subjects: Animals
Antidiuretic Hormone Receptor Antagonists
Arginine Vasopressin.blood
Benzazepines.pharmacology
Blood Pressure.drug effects
Body Weight.drug effects
Diuresis.drug effects
Female
Heart.drug effects.physiopathology
Heart Failure.etiology.physiopathology
Hemodynamics.drug effects.physiology
Lung.drug effects.physiopathology
Myocardial Infarction.complications.physiopathology
Organ Size.drug effects
Rats
Rats, Sprague-Dawley
Renin-Angiotensin System
Survival Analysis
Systole
Appears in Collections:Journal articles

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