Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13582
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dc.contributor.authorSeeman, Egoen
dc.contributor.authorHopper, John Len
dc.date.accessioned2015-05-16T03:27:52Z
dc.date.available2015-05-16T03:27:52Z
dc.date.issued1997-05-16en
dc.identifier.citationOsteoporosis International : A Journal Established As Result of Cooperation Between the European Foundation For Osteoporosis and the National Osteoporosis Foundation of The Usa; 7 Suppl 3(): S10-6en
dc.identifier.govdoc9536296en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13582en
dc.description.abstractUnderstanding of the genetic and environmental factors contributing to the differences in fracture rates between young and old, between women and men, and between races is limited. The reasons for this may partly relate to the lack of a detailed understanding of the structural basis of bone fragility. This information, although difficult to obtain because of the invasiveness of bone biopsy, will be required if advances are to occur. aBMD cannot be relied upon as an endpoint in the study of the pathophysiology of osteoporosis. Advances will require the description of the age-, gender and race-specific means and variances in trabecular number, thickness, spacing and orientation, cortical thickness, and bone size and shape in women and men of different racial groups. Subsequent comparison of the structures in young versus old, female versus male, and in racial groups may reveal the structural differences from which inferences may be made concerning the differences in fracture rates between these groups. By defining the structural basis for bone fragility, the genetic and modifiable environmental determinants of these structures may then be identified, providing hypotheses to be tested in randomized trials aimed at reducing the incidence of fractures in these groups.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAgingen
dc.subject.otherAnalysis of Varianceen
dc.subject.otherBone Densityen
dc.subject.otherCalcium, Dietaryen
dc.subject.otherCausalityen
dc.subject.otherDiseases in Twinsen
dc.subject.otherEnvironmenten
dc.subject.otherFemaleen
dc.subject.otherFractures, Spontaneous.etiologyen
dc.subject.otherGenetic Variationen
dc.subject.otherGenotypeen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherOsteoporosis.geneticsen
dc.titleGenetic and environmental components of the population variance in bone density.en
dc.typeJournal Articleen
dc.identifier.journaltitleOsteoporosis Internationalen
dc.identifier.affiliationAustin and Repatriation Medical Centre, University of Melbourne, Australiaen
dc.description.pagesS10-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/9536296en
dc.type.austinJournal Articleen
local.name.researcherSeeman, Ego
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptEndocrinology-
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